| 邹兴文,杨 丽,李伟栋.广州市173 335名农村妇女乳腺癌筛查分析[J].中国肿瘤,2018,27(8):568-572. |
| 广州市173 335名农村妇女乳腺癌筛查分析 |
| Analysis of Breast Cancer Screening Among 173 335 Women from Rural Areas in Guangzhou |
| 投稿时间：2018-02-26 |
| DOI：10.11735/j.issn.1004-0242.2018.08.A002 |
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| 中文关键词: 乳腺肿瘤 筛查 超声检查 X线检查 广东 |
| 英文关键词:breast neoplasms screening ultrasonography mammography Guangdong |
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| 中文摘要: |
| 摘 要：［目的］ 了解广州市农村妇女乳腺癌的患病情况，评价乳腺临床检查联合超声补充X线方法在人群乳腺癌筛查中的应用效果。［方法］ 筛查对象为广州市35～64岁的农村妇女，所有对象均接受乳腺临床检查和超声检查，检查结果阳性者进行组织病理学检查，检查结果可疑者补充乳腺X线检查，X线检查异常者行组织病理学检查。使用χ2检验比较各年龄组检出率的差异，使用灵敏度、特异性、约登指数进行不同筛查模式的比较。［结果］ 共筛查农村妇女173 335名，乳腺超声检查阳性率为1.15%，可疑率为5.76%，各年龄组差异有统计学意义（χ2=1492.10，P<0.001），40～44岁组阳性率最高，60～64岁组阳性率最低。2764名农村妇女接受了组织病理学检查，共检出124例乳腺癌，乳腺癌检出率为71.54/10万，各年龄组乳腺癌检出率差异有统计学意义（χ2=12.097，P=0.034），45～49岁组最高，35～39岁组最低。比较不同筛查模式发现，临床检查联合超声补充X线、临床检查联合超声、单独超声、单独临床检查的约登指数分别为0.98、0.78、0.76和0.31。［结论］ 乳腺超声检查有较强的乳腺癌检出效能，临床检查联合超声补充X线的方法适用于我国大人群的妇女乳腺癌筛查。 |
| 英文摘要: |
| Abstract：［Purpose］ To estimate the prevalence of breast cancer among women from rural area in Guangzhou，and to evaluate the efficacy of clinical breast examination combined with ultrasonography and complementary mammography for breast cancer screening. ［Methods］ A breast cancer screening program was conducted among women aged 35~64 years from rural area in Guangzhou. All women were examined by clinical breast examination and ultrasonography. The women with positive results then underwent histopathological examination；those with suspicious results were further examined by mammography，and the abnormal mammography necessitates further histopathological examination. χ2 test was used to compare detective rates among age groups. Sensitivity，specificity and Youden index of different screening approaches were compared. ［Results］ A total of 173 335 women were screened. The positive rate of breast ultrasonography was 1.15% and the suspicious rate was 5.76%. Positive rates among different age groups were varied(χ2 =1492.10，P<0.001). The highest positive rate was in age group of 40~44 years，and the lowest age group was in 60~64 years. A total of 2764 women underwent histopathological examination and 124 women were found positive with breast cancer. The detective rate of breast cancer was 71.54/105，which is significantly different among different age groups(χ2=12.097，P=0.034). The Youden index for clinical breast examination combined with ultrasonography and complementary mammography，clinical breast examination combined with ultrasonography，ultrasonography only，clinical breast examination only were 0.98，0.78，0.76 and 0.31，respectively. ［Conclusion］ Breast ultrasonography is highly effective for detection of breast cancer. Clinical breast examination combined with ultrasonography and complementary mammography may be the optimal approach for breast cancer screening. |
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