| 中文关键词: GINS2基因 肿瘤 DNA损伤 DNA复制 细胞周期 |
| 英文关键词:GINS2 gene tumor DNA damage DNA replication cell cycle |
| 基金项目:国家自然科学基金 (81672989，81702685)；江苏省卫生与计划生育委员会青年基金 (Q201501)；江苏省卫生厅青年医学人才基金 (QNRC2016648) |
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| 中文摘要: |
| 摘 要：GINS2基因是GINS家族的成员之一，与DNA的复制及损伤发生密切相关，参与细胞周期的调控，并对细胞的增殖和凋亡起到关键作用，因而与肿瘤的发生发展关系十分密切。既往国内外研究表明，GINS2是一种癌基因，在众多恶性肿瘤中高表达，促进肿瘤的发生和发展。文章就GINS2在各种肿瘤中作用的研究进展进行综述。 |
| 英文摘要: |
| Abstract：GINS2 gene is a member of GINS family，which is closely related to DNA replication and damage. It also plays an important role in multiple biological processes such as cell cycle regulation，proliferation and apoptosis；therefore，it is closely associated with tumorigenesis. Studies have shown that GINS2 is an oncogene，which is highly expressed in many malignant tumors and promotes the occurrence and development of tumors. This review focuses on the research progress on the roles of GINS2 in various cancers. |
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