| 梁国华,张清媛,赵文辉.雌激素受体阳性乳腺癌中长链非编码RNA与他莫昔芬耐药关系的研究进展[J].中国肿瘤,2018,27(9):690-694. |
| 雌激素受体阳性乳腺癌中长链非编码RNA与他莫昔芬耐药关系的研究进展 |
| Research Progress on Relationship Between LncRNA and Tamoxifen Resistance in ER Positive Breast Cancer |
| 投稿时间：2018-04-27 |
| DOI：10.11735/j.issn.1004-0242.2018.09.A010 |
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| 中文关键词: 雌激素受体（ER） 乳腺癌 他莫昔芬 耐药 长链非编码RNA |
| 英文关键词:estrogen receptor (ER) breast cancer tamoxifen resistance long non-coding RNA (lncRNA) |
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| 中文摘要: |
| 摘 要：长链非编码RNA（long non-coding RNA，lncRNA）是非编码RNA的一个大类，其在多种肿瘤中异常表达。近年来，不少研究发现lncRNA，如ROR、HOTAIR、UCA1、BCAR4，在雌激素受体阳性（ER+）乳腺癌的他莫昔芬耐药中发挥了重要作用。因此，了解lncRNA在他莫昔芬耐药中的生物学机制具有重要的临床意义。该文就lncRNA与ER+乳腺癌他莫昔芬耐药的相关研究展开综述，为ER+乳腺癌他莫昔芬耐药的预防及治疗提供新思路。 |
| 英文摘要: |
| Abstract：Long non-coding RNA (lncRNA) is a large class of non-coding RNA，which is abnormal in multiple tumors. In recent years，many studies have found that lncRNAs，such as ROR，HOTAIR，UCA1 and BCAR4，play an important role in drug resistance of tamoxifen in ER+ breast cancer. Therefore，it is of great clinical significance to understand the biological mechanism of lncRNA in tamoxifen resistance. In this article，the related studies of lncRNA and tamoxifen resistance in ER+ breast cancer are reviewed to provid new thoughts to the prevention and treatment for ER+ breast cancer with tamoxifen resistance. |
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