| 郭鱼波,王春晖,裴晓华.乳腺癌细胞上皮间质转化的分子机制及其防治的研究进展[J].中国肿瘤,2018,27(12):933-943. |
| 乳腺癌细胞上皮间质转化的分子机制及其防治的研究进展 |
| Research Progress on Molecular Mechanism of Epithelial-mesenchymal Transition in Breast Cancer Cells and Its Prevention and Treatment |
| 投稿时间：2018-07-27 |
| DOI：10.11735/j.issn.1004-0242.2018.12.A008 |
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| 中文关键词: 乳腺癌转移 上皮间质转化 中医药 |
| 英文关键词:breast cancer metastasis epithelial-mesenchymal transition traditional Chinese medicine |
| 基金项目:国家自然科学基金委面上项目（81774319）；北京中医药大学2018年自主选题在读研究生项目（2018-JYBZZ-XS235） |
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| 中文摘要: |
| 摘 要：上皮间质转化(epithelial-mesenchymal transition，EMT)是恶性肿瘤上皮细胞向间质表型转化的启动过程，可促进恶性肿瘤的侵袭和转移。本文综述了乳腺癌EMT的分子标志物包括表面标志物、支架标志物和相关调控因子、相关信号通路及缺氧微环境等。乳腺癌细胞EMT会导致内分泌治疗和化疗耐药，机制可能与乳腺癌上皮细胞特性、雌激素受体及乳腺癌干细胞活性改变有关。基础研究表明中医药可逆转乳腺癌EMT，但是相关临床研究及其作用机制的文献报道较少，尚需进一步探索。明确乳腺癌细胞EMT的分子机制，有利于乳腺癌细胞转移和耐药的深入研究，并为临床上乳腺癌的靶向调控及中医药治疗提供新的思路。 |
| 英文摘要: |
| Abstract：Epithelial-mesenchymal transition(EMT) is the initiation process of malignant tumor epi-thelial cells to mesenchymal phenotype，which can promote the invasion and metastasis of malignant tumors. This article reviews the EMT molecular markers in breast cancer，including surface markers，scaffold markers，related regulatory factors and signaling pathways，and the hypoxic microenvironment. Furthermore，the EMT of breast cancer cells will lead to resistance to endocrine therapy and chemotherapy，in which the changes of breast cancer epithelial cell characteristics，estrogen receptor and breast cancer stem cell activity may be involved. Traditional Chinese Medicine could reverse breast cancer EMT，while clinical research and its mechanism still need further exploration. To clarify the molecular mechanism of EMT may contribute to the further study of metastasis and drug resistance of breast cancer cells，and provide new ideas for the clinically targeted regulation and the treatment with Traditional Chinese Medicine for breast cancer. |
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