刘维辉,陈俊毅,李毅宁.外泌体应用于膀胱癌诊疗的基础与临床研究进展[J].中国肿瘤,2019,28(1):50-54.
外泌体应用于膀胱癌诊疗的基础与临床研究进展
Research Progress of Exosomes in Diagnosis and Treatment of Bladder Cancer
投稿时间:2018-10-02  
DOI:10.11735/j.issn.1004-0242.2019.01.A007
中文关键词:  外泌体  膀胱癌  肿瘤标志物  诊断  治疗
英文关键词:exosomes  bladder cancer  tumor markers  diagnosis  treatment
基金项目:福建省自然科学基金(2017J01269)
作者单位
刘维辉 福建医科大学附属第二医院 
陈俊毅 福建医科大学附属第二医院 
李毅宁 福建医科大学附属第二医院 
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中文摘要:
      摘 要:膀胱癌是泌尿系统最常见的恶性肿瘤,其术后复发和进展一直是临床关注的焦点问题。外泌体是由细胞内多囊泡体与细胞膜融合后释放到细胞外基质中的膜性囊泡。通过携带DNA、RNA、miRNA、非编码RNA和蛋白质等,实现细胞间生物信息的交换和传递。近来的研究表明外泌体参与了膀胱癌的侵袭、转移及进展过程,文章就外泌体应用于膀胱癌诊断和治疗的基础和临床研究进展进行综述。
英文摘要:
      Abstract:Bladder cancer is the most common malignant tumor in the urinary system. Postoperative recurrence and progression have been the focus of clinical researches. Exosomes are membranous vesicles that are released into the extracellular matrix by fusion of intracellular polyvesicular bodies with cell membranes. Exosomes can exchange and transfer intercellular biological information through DNA,RNA,miRNA,non-coding RNA and proteins. Recent studies have shown that exosomes are involved in the invasion,metastasis and progression of bladder cancer. This article reviews the progress in the basic research and clinical application of exosomes in the diagnosis and treatment of bladder cancer.
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