| 陈朝虎,姚志强,汉大黎.局部进展性肾癌术后靶向治疗的研究进展[J].中国肿瘤,2019,28(6):450-455. |
| 局部进展性肾癌术后靶向治疗的研究进展 |
| Progress of Targeted Therapy for Locally Advanced Renal Cell Carcinoma |
| 投稿时间：2019-03-08 |
| DOI：10.11735/j.issn.1004-0242.2019.06.A010 |
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| 中文关键词: 局部进展性肾癌 靶向药物 |
| 英文关键词:locally advanced renal cell carcinoma targeted drugs |
| 基金项目:甘肃省卫生行业科研计划项目（GSWSKY2017?鄄10）；萃英科技创新项目（CY2017?鄄BJ16）；兰州市城关区科技局科技攻关项目（2017KJGG0052） |
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| 中文摘要: |
| 摘 要：靶向治疗作为一种新型治疗模式，在肾癌的姑息性治疗和术前辅助治疗方面均获得了显著的疗效，因此人们对其填补局部进展性肾癌术后辅助治疗的空白给予了新的期望。本文对局部进展性肾癌的特点及靶向药物的相关作用机制作简要介绍，并通过比较分析相关临床试验差异，找出影响靶向药物术后辅助治疗疗效的可能因素，进而探讨靶向药物用于局部进展性肾癌术后辅助治疗的价值和前景。 |
| 英文摘要: |
| Abstract：Targeted therapy，as a novel treatment modality，has achieved significant progress in both palliative and preoperative adjuvant treatment of renal cell carcinoma(RCC)，new expectations have been given for its application in postoperative adjuvant treatment of locally advanced RCC. This article briefly introduces the characteristics of locally advanced RCC and the mechanism of targeted drugs，and analyzes the factors affecting the efficacy of targeted-drugs in postoperative adjuvant therapy from relevant clinical trials. The value and prospects of targeted drugs in postoperative therapy for locally advanced RCC are also discussed. |
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