| 丁贤彬,吕晓燕,毛德强.2010~2017年重庆市宫颈癌疾病负担变化趋势分析[J].中国肿瘤,2019,28(9):657-662. |
| 2010~2017年重庆市宫颈癌疾病负担变化趋势分析 |
| Trend Analysis of Disease Burden of Cervical Cancer from 2010 to 2017 in Chongqing |
| 投稿时间：2018-10-10 |
| DOI：10.11735/j.issn.1004-0242.2019.09.A004 |
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| 中文关键词: 宫颈癌 发病率 死亡率 疾病负担 年度变化百分比 重庆 |
| 英文关键词:cervical cancer incidence mortality burden of disease annual percent of change Chongqing |
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| 中文摘要: |
| 摘 要：［目的］ 了解重庆市宫颈癌疾病负担现状及变化趋势。［方法］ 收集2010至2017年重庆市11个肿瘤登记点宫颈癌（ICD-10：C53）发病、死亡的资料，统计分析宫颈癌发病率、死亡率、标化发病率/死亡率、年龄别发病率/死亡率、年度变化百分比（APC）、伤残调整生命年(DALYs)、早死所致的寿命损失年(YLLs)、残疾所致寿命年损失(YLDs)等指标。率的比较采用卡方检验，APC趋势变化采用t检验（?琢=0.05）。［结果］ 重庆市宫颈癌粗发病率和标化发病率分别由2010年的8.03/10万、7.78/10万上升至2017年18.65/10万、14.72/10万，APC分别为16.77%与12.30%，变化趋势差异有统计学意义（t值分别为9.99、10.25，P<0.01）。宫颈癌粗死亡率与标化死亡率分别由2010年的3.77/10万、3.51/10万上升到2017年的7.36/10万、 6.83/10万，APC分别为17.59%与16.30%，变化趋势差异有统计学意义（t值分别为5.30、4.76，P<0.05）。宫颈癌的YLLs率、YLDs率、DALYs率分别由2010年的1.27千人年、0.03千人年、1.30千人年上升至2017年的2.17千人年、0.12千人年、2.29千人年，APC分别为10.74%、25.86%、11.29%，变化趋势差异有统计学意义（t值分别为4.79、8.02、5.04，P<0.05）。农村地区宫颈癌DALYs以13.54%的速度上升。［结论］ 重庆市宫颈癌发病率、死亡率、疾病负担高于全国平均水平，呈逐年上升的趋势，农村地区上升趋势更为明显，应切实做好宫颈癌的三级预防工作。 |
| 英文摘要: |
| Abstract：［Purpose］ To analyze the trends of disease burden of cervical cancer change in Chongqing Municipality from 2010 to 2017. ［Methods］ Newly diagnosed cases and death cases of cervical cancer(ICD-10：C53) in 11 cancer registrations in Chongqing Municipality from 2010 to 2017 were collected. The incidence，mortality，age-standardized incidence rates by Chinese standard population(ASIRC)，age-standardized mortality rates by Chinese standard population(ASMRC），age-specific incidence and mortality，annual percent of change(APC)，disability adjusted life years(DALYs)，years of life lost with premature death(YLLs)，years lived with disability(YLDs) were analyzed. The differences of rates between urban and rural area were compared by Chi-square test. The trend change(APC) was examined by t test(α=0.05). ［Results］ The crude incidence and ASIRC of cervical cancer increased from 8.03/105 and 7.78/105 in 2010 to 18.65/105 and 14.72/105 in 2017，respectively with the APC of 16.77% and 12.30%，respectively. Their trend changes were significantly different( t value 9.99 and 10.25，P<0.01). The crude mortality and ASMRC of cervical cancer increased from 3.77/105 and 3.51/105 in 2010 to 7.36/105 and 6.83/105 in 2017，with the APC of 17.59% and 16.30%，respectively( t=5.30 and 4.76，P<0.05). The rates of YLLs，YLDs and DALYs of cervical cancer increased from 1.27/1000 person years，0.03/1000 person years and 1.30/1000 person years in 2010 to 2.17/1000 person years，0.12/1000 person years and 2.29/1000 person years in 2017，respectively. Their APCs were 10.74%，25.86% and 11.29% respectively(t=4.79，8.02 and 5.04，P<0.05). The rate of DALYs of cervical cancer increased by 13.54% from 2010 to 2017 in rural area of Chongqing. ［Conclusion］ The incidence，mortality and disease burden of cervical cancer are higher than the average levels in China and increased year by year. Moreover，the trend changes have increased significantly in rural area. |
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