| 贵 鹏,李朝旭,吴 昊.MiRNA靶向调控骨肉瘤耐药机制的研究进展[J].中国肿瘤,2019,28(9):694-698. |
| MiRNA靶向调控骨肉瘤耐药机制的研究进展 |
| Advances in MiRNA Targeting Regulation of Drug Resistance in Osteosarcoma |
| 投稿时间：2019-04-29 |
| DOI：10.11735/j.issn.1004-0242.2019.09.A010 |
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| 中文关键词: 骨肉瘤 miRNAs 耐药 靶向调控 |
| 英文关键词:osteosarcoma miRNAs drug resistance targeting regulation |
| 基金项目:国家自然科学基金资助项目(81360400) |
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| 中文摘要: |
| 摘 要：MicroRNAs (miRNAs)是一类长度为22～25个核苷酸的非编码小分子RNA，具有高度的保守性、时序性和特异性。MiRNAs参与调节多种生物活动和病理过程，包括肿瘤的形成和发展。骨肉瘤是一种具有很强转移性及侵袭性的恶性肿瘤，目前骨肉瘤的治疗仍以手术及化疗为主，然而肿瘤细胞对化疗药物的耐药性是骨肉瘤治疗及预后所面临的主要问题。近年来，研究发现miRNA可调控肿瘤细胞的多种位置靶点基因，降低甚至逆转肿瘤细胞对化疗药物的抗性，对miRNA的研究可能成为改变骨肉瘤耐药机制新的治疗方向。该文对miRNA调控骨肉瘤的耐药机制作一综述。 |
| 英文摘要: |
| Abstract：MicroRNAs(miRNAs) are non-coding small RNAs of 22～25 nucleotides in length，with high conservation，sequence and specificity. MiRNAs are involved in the regulation of a variety of biological activities and pathological processes，including the formation and progression of the tumor. Osteosarcoma is a highly metastatic and invasive malignant tumor. At present，the surgery and chemotherapy are still mainly treatment for osteosarcoma，however，the drug resistance of tumor cells is the primary issue for treatment and prognosis of patients. In recent years，it has been found that miRNA can regulate multiple target genes in tumor cells，which can reduce or even reverse the resistance of tumor cells to chemotherapeutic drugs. The study of miRNA may become a new way to change the drug resistance mechanism of osteosarcoma. This article reviews the development of mechanisms for miRNA regulation of drug-resistance in osteosarcoma. |
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