宋正波,陆 舜,冯继锋.中国肿瘤相关性贫血发生率及治疗现状的流行病学调查研究[J].中国肿瘤,2019,28(9):717-722.
中国肿瘤相关性贫血发生率及治疗现状的流行病学调查研究
Prevalence and Treatment of Cancer-related Anemia:A Nationwide Survey in China
投稿时间:2019-06-09  
DOI:10.11735/j.issn.1004-0242.2019.09.A014
中文关键词:  肿瘤相关性贫血  发生率  治疗  中国
英文关键词:cancer-related anemia  prevalence  treatment  China
基金项目:
作者单位
宋正波 中国科学院肿瘤与基础医学研究所中国科学院大学附属肿瘤医院浙江省肿瘤医院 
陆 舜 上海交通大学附属胸科医院 
冯继锋 江苏省肿瘤医院 
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中文摘要:
      摘 要:[目的]调查中国恶性肿瘤患者的贫血发生率及贫血治疗状况。[方法] 对全国97家医院成年恶性肿瘤患者进行开放性、多中心、单次探访、非干预性的横断面调查。通过回顾患者病史,填写贫血调查表格,收集相关数据,如肿瘤类型、疾病分期、肿瘤治疗情况等。根据美国国立癌症研究所(NCI)的贫血分级标准将血红蛋白水平分为5级,以评估贫血的严重程度。[结果] 共纳入来自全国97家医院的7324例有效病例,患者平均血红蛋白(Hb)为(114.36±19.60)g/L,贫血发生率为49.24%(3606/7324),其中1级贫血28.84%,2级贫血15.91%,3级贫血3.66%,4级贫血0.83%。不同肿瘤类型中,泌尿系统肿瘤伴贫血发生率最高(62.89%),其次是妇科肿瘤(60.32%) 和胃肠道肿瘤 (51.13%)。在贫血患者中,高达92.84%未给予任何纠正贫血的措施和治疗;接受贫血治疗的患者中,促红细胞生成素(EPO)治疗的比例为44.96%,输血治疗的比例为31.39%,铁剂治疗的比例为6.59%。[结论] 目前国内肿瘤相关性贫血发生率较高,但相应的贫血治疗率极低,应加强肿瘤患者的贫血管理。
英文摘要:
      Abstract:[Purpose] To investigate the prevalence and treatment of cancer-related anemia(CRA) in China. [Methods] An open-ended,multi-center,single-visit,non-interventional,cross-sectional study about CRA was undertaken in 97 hospitals in China during April to July 2012. [Results] A total of 7324 evaluable patients were recruited from 97 hospitals in China. Median hemoglobin(Hb) of all patients was(114.36±19.60)g/L. CRA occurred in 3606 patients(49.24%),including 2112 cases of mild anemia(28.84%),1165 cases of moderate anemia(15.91%),268 cases of severe anemia(3.66%),and 61 cases of life-threatening anemia(0.83%). Patients with urogenital cancer had the highest rate of CRA(62.89%),followed by patients with gynecological(60.32%) and gastrointestinal cancers(51.13%). As high as 92.84% of the patients with CRA did not receive any anemia treatment. Of the 258 patients with CRA who did receive anemia treatment,44.96% received erythropoietin(EPO),31.39% had a blood transfusion,6.59% had iron supplement. [Conclusion] The survey demonstrates that CRA is frequently observed in Chinese cancer patients,and a large amount of patients do not receive treatment for anemia,suggesting that CRA management must be improved among cancer patients.
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