| 白茹梦,卓帅帅,孙苗苗.长链非编码RNA在肿瘤细胞自噬中的调控作用[J].中国肿瘤,2020,29(5):373-378. |
| 长链非编码RNA在肿瘤细胞自噬中的调控作用 |
| Regulation of Long Non-Coding RNA in Tumor Cell Autophagy |
| 中文关键词 修订日期：2019-10-09 |
| DOI：10.11735/j.issn.1004-0242.2020.05.A009 |
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| 中文关键词: lncRNA 自噬 肿瘤 |
| 英文关键词:lncRNA autophagy tumor |
| 基金项目:国家自然科学基金(81773109) |
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| 中文摘要: |
| 摘 要：LncRNA是一类长度大于200nt，并且没有蛋白编码功能的RNA。研究发现lncRNA在肿瘤细胞的增殖、侵袭、迁移、物质代谢和血管形成等方面发挥重要作用。自噬是细胞的 “自食”现象，是哺乳动物发育、细胞生理和免疫反应的关键，然而高水平自噬也会在一定程度上引起细胞凋亡。研究表明lncRNA是细胞自噬的新型调控因素，可以在多种机制上调节自噬的进程，进而影响肿瘤的发生、发展。全文论述lncRNAs在肿瘤细胞中调控自噬水平及其机制。 |
| 英文摘要: |
| Abstract：LncRNA is a kind of RNA with length larger than 200nt which has no function of protein coding. Studies have proved that lncRNAs plays a pivotal role in tumor cell proliferation，invasion，migration，metabolism and angiogenesis.Autophagy is a phenomenon of“self-feeding” in cells，which exerts extraordinary functions on mammalian development，cell physiology and immune response. However，high levels of autophagy can also cause cell death to some extent. Studies have shown that lncRNAs is a new factor that can regulate the process of autophagy in a variety of mechanisms，which in turn induces the occurrence and development of tumor. This article reviews the regulation of autophagy in lncRNAs in tumor cells and its mechanism. |
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