| 张 妍,刘爱国.NKG2D受体配体系统介导肿瘤免疫逃逸的研究进展[J].中国肿瘤,2020,29(8):602-607. |
| NKG2D受体配体系统介导肿瘤免疫逃逸的研究进展 |
| Research Progress of Tumor Immune Escape Mediated by NKG2D and Its Ligands |
| 中文关键词 修订日期：2020-04-29 |
| DOI：10.11735/j.issn.1004-0242.2020.08.A008 |
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| 中文关键词: NKG2D NKG2D配体 肿瘤细胞 免疫逃逸 免疫治疗 |
| 英文关键词:NKG2D NKG2D ligands(NKG2DL) tumor immune escape immunotherapy |
| 基金项目:国家自然科学基金（81472706、81874187） |
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| 中文摘要: |
| 摘 要：NK细胞作为机体固有免疫的重要组成部分，在肿瘤免疫监视机制中起重要作用。NKG2D是NK细胞重要的激活受体，通过识别位于肿瘤细胞表面的NKG2D配体，介导细胞毒效应清除肿瘤细胞。然而存在多种因素可影响NKG2D受体与配体的表达，阻断了NKG2D信号转导，为肿瘤细胞免疫逃逸提供可能。NKG2D受体配体系统还可作为临床诊疗的靶点，为肿瘤患者诊断、治疗以及评估预后提供依据。本文就NKG2D受体配体系统介导的肿瘤细胞免疫逃逸的机制以及目前已有的针对性免疫治疗方法进行综述，为临床应用提供更多思路。 |
| 英文摘要: |
| Abstract：NK cells，as an important part of innate immunity，play an important role in tumor immune surveillance mechanism. NKG2D is an important activated receptor of NK cells. By recognizing NKG2D ligand located on the surface of tumor cells，NKG2D mediates cytotoxic effect to eliminate tumor cells. However，there are many factors that can affect the expression of NKG2D receptors and ligands，inhibit the signal transduction of NKG2D，leading to tumor cell immune escape. NKG2D receptor/ligand system can also be used as a target for clinical diagnosis，treatment and prognosis evaluation in cancer patients. This article reviews the mechanism of NKG2D receptor/ligand system mediated immune escape of tumor cells and related targeting immunotherapy for clinical application. |
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