| 陈文婕,董玮琪,乔丽颖.2015年内蒙古自治区女性乳腺癌发病与死亡情况及2010—2015年趋势分析[J].中国肿瘤,2020,29(10):736-743. |
| 2015年内蒙古自治区女性乳腺癌发病与死亡情况及2010—2015年趋势分析 |
| Incidence and Mortality of Female Breast Cancer in Inner Mongolia in 2015 and Its Trend from 2010 to 2015 |
| 中文关键词 修订日期：2020-04-27 |
| DOI：10.11735/j.issn.1004-0242.2020.10.A004 |
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| 中文关键词: 乳腺癌 发病率 死亡率 趋势 内蒙古 |
| 英文关键词:breast neoplasms incidence mortality trend Inner Mongolia |
| 基金项目:内蒙古自治区卫生计生委卫生计生科研计划项目（201702042） |
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| 中文摘要: |
| 摘 要：［目的］ 分析2015年内蒙古肿瘤登记地区女性乳腺癌发病与死亡现状及2010—2015年内蒙古女性乳腺癌发病与死亡趋势，为内蒙古乳腺癌防治提供基础信息。［方法］ 按照全国肿瘤登记中心制定的审核方法和评价标准，对内蒙古符合要求的10个肿瘤登记处上报的女性乳腺癌发病、死亡和人口数据进行汇总分析。按城乡、性别、年龄别分层分析女性乳腺癌发病与死亡粗率、标化率、累积率（0~74岁）及顺位和构成等指标，并结合内蒙古2015年户籍人口资料，估算全区女性乳腺癌发病（死亡）数。应用Joinpoint统计软件分析2010—2015年内蒙古女性乳腺癌发病和死亡趋势，估算总体年度变化百分比（annual percent change，APC）。中国人口标化率（中标率）和世界人口标化率（世标率）分别采用2000年人口普查的年龄构成和Segi’s标准人口的年龄构成。［结果］ 2015年10个肿瘤登记处共覆盖人口4 200 478人，其中城市2 372 312人，农村1 828 166人。2015年内蒙古自治区估计女性乳腺癌新发病例4074例，死亡病例1137例。内蒙古肿瘤登记地区女性乳腺癌发病粗率为35.19/10万，中标率为24.90/10万，世标率为23.61/10万，0~74岁累积发病率为2.58%，占女性全部恶性肿瘤发病的15.37%，位居女性恶性肿瘤发病顺位的第2位。女性乳腺癌粗死亡率为8.80/10万，中标率为6.08/10万，世标率为5.87/10万，0~74岁累积死亡率为0.63%，占女性全部恶性肿瘤死亡的7.99%，位居恶性肿瘤死亡顺位的第5位。乳腺癌发病率城市均高于农村。内蒙古肿瘤登记地区女性乳腺癌发病率在25岁后上升迅速，50~岁年龄组达到高峰，随后下降，60~岁年龄组呈现第二个小高峰；死亡率在35岁后快速上升，80~岁年龄组达到峰值。2010—2015年内蒙古肿瘤登记地区女性乳腺癌发病中标率APC为2.39%，死亡中标率APC为-4.77%，但都无统计学意义。从年龄别趋势来看，60~74岁年龄段在2010—2015年发病中标率（APC=-8.46%）呈上升趋势，且差异有统计学意义。［结论］ 乳腺癌是内蒙古女性人群主要恶性肿瘤之一，针对城乡女性乳腺癌发病死亡特点进一步加强乳腺癌的防治。 |
| 英文摘要: |
| Abstract：［Purpose］ To analyze the incidence，mortality and trend of female breast cancer in Inner Mongolia cancer registration area in 2010—2015.［Methods］ According to the audit methods and evaluation standards formulated by the National Cancer Registration Center of China，the incidence，mortality and population data of female breast cancer reported by 10 cancer registries in Inner Mongolia were analyzed. The data were stratified by urban and rural，gender and age groups. The crude rates of female breast cancer incidence and mortality，standardized incidence/mortality rates，cumulative incidence/mortality rates（0~74 years），rank and ratio were calculated. The incidence(death) of female breast cancer in the whole region was based on the household registration data of Inner Mongolia in 2015. Chinese population census in 2000 and Segi’s population were used for age-standardized incidence and mortality rates.［Results］ Qualified 10 cancer registries covered a population of 4 200 478 people(2 372 312 in urban areas and 1 828 166 in rural areas) in 2015. In 2015，4074 new cases and 1137 deaths of female breast cancer was estimated in the whole Inner Mongolia Autonomous Region. The crude incidence rate，age-standardized rate of incidence by Chinese standard population，and age-standardized rate of incidence by world standard population，the cumulative incidence of 0~74 years old were 35.19/105，24.90/105，23.61/105 and 2.58%，respectively，accounting for 15.37% of all new female cancer cases，and ranking the second in the incidence of female malignant tumors. The crude mortality rate，age- standardized rate of mortality by Chinese standard population，and age- standardized rate of mortality by world standard population，the cumulative mortality of 0~74 years old were 8.80/105，6.08/105，5.87/105 and 0.63%，respectively，accounting for 7.99% of all female cancer deaths，and ranking the fifth in the mortality of female malignant tumors. The crude incidence was higher in urban than in rural areas(P=0.004).The age-specific incidence rates of breast cancer increased after 25 years old and peaked at age group of 50~，then decreased，the second highest peak was 60~ years old. The age-specific mortality rates of breast cancer increased after 35 years old and peaked at age group of 80~. From 2010 to 2015，the annual percentage changes(APC) of incidence ASRC in the cancer registration area of Inner Mongolia was 2.39%(P=0.39)，and the APC of mortality ASRC was -4.77%(P=0.51). From the age-specific trend，APC of incidence ASRC was 8.46% in the 60~74 age group showing an increasing trend in 2010—2015(P=0.01). ［Conclusion］ Breast cancer is one of the most common malignant tumor in Inner Mongolia，the prevention measure should be implemented according to the different characteristic between urban and rural. |
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