| 顾建华,王少明,魏文强.性激素与胃癌发病风险的研究进展[J].中国肿瘤,2020,29(10):768-776. |
| 性激素与胃癌发病风险的研究进展 |
| Progress in Research on Relationship Between Sex Hormones and Gastric Cancer |
| 中文关键词 修订日期：2020-06-02 |
| DOI：10.11735/j.issn.1004-0242.2020.10.A009 |
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| 中文关键词: 雌激素 雄激素 环境激素 胃癌 |
| 英文关键词:estrogen androgen environmental hormone gastric cancer |
| 基金项目:国家重点研发计划(2016YFC0901400，404)；中国医学科学院医学与健康科技创新工程（2019?鄄I2M?鄄2?鄄004） |
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| 中文摘要: |
| 摘 要：胃癌在发病率上存在明显的性别差异，男性高于女性。既往研究指出，这一差异不能完全归因于吸烟、饮酒、幽门螺杆菌感染等已知危险因素，性激素也可能是导致这一差异的重要原因。本文从基础学与流行病学研究等角度，综述了内源性雌激素、雄激素、环境激素与胃癌发病风险关系的相关研究，以期为胃癌的发病机制探索和危险因素防控提供科学依据。 |
| 英文摘要: |
| Abstract：The morbidity of gastric cancer is higher in men than that in women. Previous studies have revealed that this gender difference cannot be attributed solely to known risk factors such as smoking，alcohol consumption，and Helicobacter pylori infection. It has been speculated that sex hormonal factors may play a role in the development of gastric cancer. This article summarizes the progress in the research on the relationship of endogenous sex hormones and environmental hormones with gastric cancer from the perspective of basic science and epidemiological studies in order to provide scientific evidence for the pathogenesis of gastric cancer as well as the prevention and control of risk factors. |
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