| 中文关键词: 肝癌 筛查 |
| 英文关键词:liver cancer screening |
| 基金项目:中国医学科学院医学与健康科技创新工程（2019-I2M-2-004）；深圳医疗卫生三名工程（SZSM201911015） |
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| 中文摘要: |
| 摘 要：肝癌是我国常见的恶性肿瘤之一，严重威胁居民健康，全球近一半的新发和死亡病例发生在中国。危险因素的复杂多样为推行肝癌一级预防带来了一定困难。在高危人群中进行筛查和早诊早治是降低肝癌负担的有效措施。确定肝癌高危人群和选择合适的筛查方法是肝癌筛查的重点和难点。肝癌发病风险预测模型是识别和浓缩肝癌高危人群的有力工具。融合基因、临床指标、分子标志物和肝癌独立危险因素已成为构建和优化肝癌发病风险预测模型的新趋势。目前研究已证实筛查可以显著提高筛查人群生存率，但能否降低肝癌死亡率尚无定论。精准定位高危人群，优化筛查流程，提高早期检出率是下一步研究的重点。同时还应加强人群健康教育，普及防治知识以提高居民对癌症筛查的认识和参与度。 |
| 英文摘要: |
| Abstract：Liver cancer is one of the most common cancers，nearly half cases and deaths globally occur in China，posing a great threat to human health and lives. The complexity and diversity of risk factors make it difficult to implement primary prevention of liver cancer. The early detection and treatment through screening high-risk population is an effective measure to reduce liver cancer burden. To identify high-risk population and to use appropriate screening methods are the key issues for liver cancer screening. Risk prediction model for liver cancer is a useful tool to identify high-risk population of liver cancer，which can be optimized by the combination of gene detection，clinical indicator，biomarker and risk factor assessment. Accurate identifying high-risk individuals，optimizing screening procedures，and improving early detection rate should be focused for further researches. The healthy education and knowledge popularization on cancer prevention and control are necessary for improving the awareness and increasing participation rates for liver cancer screening among residents. |
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