| 中文关键词: 肺癌 发病率 发病年龄 趋势分析 全球 |
| 英文关键词:lung cancer incidence age trend analysis the whole world |
| 基金项目:中国医学科学院医学与健康科技创新工程（2021-I2M-1-011） |
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| 中文摘要: |
| 摘 要：［目的］ 根据国际癌症登记协会发布的全球肺癌发病数据，分析全球部分高发地区肺癌的发病趋势及年龄变化情况。［方法］ 从《五大洲癌症发病率》时间趋势数据库提取1998—2012年的连续监测数据，利用来自亚洲、北美洲、欧洲、大洋洲共37个国家的101个肿瘤登记处的全部肺癌发病数据，计算全球各个高发地区肺癌发病率的平均年度变化百分比（AAPC），并构建1913—2012年的出生队列，利用队列发病率、平均发病年龄和年龄别发病构成等指标，分析肺癌发生与年龄的关系。［结果］ 1998—2012年全球肺癌高发地区的女性发病率均呈现上升趋势，按人口年龄结构标化后，除了北美洲表现出下降趋势，其AAPC为-0.7%（95%CI：-1.1%~-0.4%），其他地区的上升趋势有所减缓；男性发病率亚洲呈上升趋势，欧洲和北美洲呈现下降趋势，按人口年龄结构标化后，男性发病率均呈现下降趋势，欧洲和北美洲下降趋势较标化之前更显著，AAPC分别为-1.6%（95%CI：-1.9%~-1.3%）和-2.5%（95%CI：-2.6%~-2.3%）。1998—2012年各地区肺癌平均发病年龄均呈现逐年递增的趋势，亚洲男性增幅最大，每年增加约0.15岁；按人口年龄结构标化后，大部分地区男女人群的平均发病年龄较标化之前增幅有所减缓，而亚洲女性平均发病年龄则逐年递减，每年减少约0.05岁。［结论］ 1998—2012年全球不同高发地区的肺癌发病率趋势和发病年龄变化各异，大多数地区都表现出发病年龄后移的趋势，全球人口老龄化普遍存在，从而影响实际发病年龄的变化趋势，防控策略应针对不同地区不同年龄人群展开。 |
| 英文摘要: |
| Abstract： ［Purpose］ To analyze the global trends of incidence of lung cancer.［Methods］ The annual lung cancer incidence data and corresponding population at-risk data (1998—2012) from Asia， Northern America， Europe and Oceania were extracted from Cancer Incidence in Five Continents Time Trends(CI5plus) of the International Association of Cancer Registries(IACR). The average annual percentage change(AAPC) was calculated to examine the trends of incidence. Age-period-cohort from 1913 to 2012 was constructed. The cohort incidence rate， age-standardized mean age at diagnosis and proportion of incidence cases by age were calculated. ［Results］ The crude incidence rate of lung cancer in females presented an upward trend in all selected regions from 1998 to 2012; while the age-standardized incidence rate(ASR) showed a downward trend， except in Northern America where the AAPC was -0.7% during the period of 1998—2012(95%CI： -1.1%~ -0.4%). The crude incidence rate in males presented an upward trend in Asia， but showed downward trends in Europe and in Northern America; while the ASR incidence showed a downward trends in all selected regions， particularly in Europe and in Northern America the AAPCs were -1.6%(95%CI： -1.9%~-1.3%) and -2.5%(95%CI： -2.6%~-2.3%)， respectively. The mean age at diagnosis increased from 1998 to 2012 in both genders in all selected regions， that of males in Asia was more marked with an annual increase of 0.15 years. After age-standardized， except for females in Asia in whom the age at diagnosis had an annual decrease of 0.05 years， while for other populations the age at diagnosis still kept increasing but the trends were slowed down. ［Conclusion］ From 1998 to 2012， the trends of incidence and age change for global lung cancer incidence varied in different regions of the world， indicating that prevention and control strategies should be targeted at different age groups in different regions. |
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