| 徐 英,李志学,马 艳,等.1990—2019年中国成年人归因于2型糖尿病的癌症疾病负担研究[J].中国肿瘤,2022,31(12):959-966. |
| 1990—2019年中国成年人归因于2型糖尿病的癌症疾病负担研究 |
| Cancer Disease Burden Attributable to Type 2 Diabetes Mellitus Among Adults in China， 1990—2019 |
| 投稿时间：2022-06-07 |
| DOI：10.11735/j.issn.1004-0242.2022.12.A004 |
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| 中文关键词: 2型糖尿病 癌症 疾病负担 成年人 中国 |
| 英文关键词:type 2 diabetes mellitus cancer burden of disease adult China |
| 基金项目:深圳市科技计划(JCYJ20210324125202006) |
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| 中文摘要: |
| 摘 要：［目的］ 分析1990—2019年中国成年人归因于2型糖尿病(type 2 diabetes mellitus，T2DM)的癌症疾病负担情况。［方法］ 利用全球疾病负担(Global Burden of Disease，GBD) 2019年的数据，采用Joinpoint模型评估分析我国部分癌症归因于T2DM的疾病负担的平均年度变化百分比(average annual percentage change，AAPC)。［结果］ 2019年我国居民归因于T2DM的癌症死亡率和伤残调整寿命年(disability-adjusted life years，DALYs)率分别为8.712/10万和187.899/10万，较1990年分别增长110.54%和87.29%；归因死亡率和DALYs率除肝癌外，胰腺癌，卵巢癌，结直肠癌，气管、支气管和肺癌，女性乳腺癌和膀胱癌均呈现上升趋势；性别和年龄分组结果显示，25~49岁组归因死亡率和DALYs率的AAPC呈显著上升趋势的癌种为结直肠癌(男：3.59%和3.61%；女：0.88%和0.88%）、膀胱癌（男：1.53% 和1.68%）、胰腺癌（男：4.48%和4.40%；女：2.56%和2.49%）、卵巢癌（2.37%和2.33%）；70+岁组气管、支气管和肺癌（男：1.89%和1.64%；女：1.62%和1.33%）和女性乳腺癌（1.06%和1.00%）归因死亡率和DALYs率的AAPC上升较快。［结论］ 气管、支气管和肺癌，结直肠癌，女性乳腺癌归因于T2DM的疾病负担较重；除肝癌外，归因于T2DM的癌症疾病负担呈上升趋势，其中胰腺癌、卵巢癌、结直肠癌上升较快，且男性高于女性。要重点关注25~49岁人群结直肠癌、膀胱癌、胰腺癌、卵巢癌及70+岁组气管、支气管和肺癌与女性乳腺癌归因于T2DM的疾病负担，加强癌症风险防控。 |
| 英文摘要: |
| Abstract： ［Purpose］ To analyze the disease burden and trends of cancer attributable to type 2 diabetes mellitus(T2DM) among adults in China from 1990 to 2019. ［Methods］ Based on the data of the Global Burden of Disease Study 2019(GBD 2019)， the average annual percentage change(AAPC) was used to analyze the time trend of disease burden of seven types of cancer attributed to T2DM in China. ［Results］ Cancer mortality and disability-adjusted life years(DALYs ) due to T2DM in China in 2019 were 8.712/105 and 187.899/105， increasing by 110.54% and 87.29% compared with 1990， respectively. The attributable mortality and DALYs rates of pancreatic cancer， ovarian cancer， colorectal cancer， tracheal， bronchus and lung cancer， female breast cancer， and bladder cancer were on the rise，but not for the liver cancer. The stratification by gender and age showed that the AAPC of attributable mortality rate and DALYs rate of colorectal cancer(male： 3.59% and 3.61%； female： 0.88% and 0.88%)， bladder cancer(male： 1.53% and 1.68%)， pancreatic cancer(male：4.48% and 4.40%； female： 2.56% and 2.49%)， ovarian cancer(2.37% and 2.33%) in the age group of 25~49 were increased significantly； the AAPC of attributable mortality rate and DALYs rate of tracheal， bronchus and lung cancer(male： 1.89% and 1.64%； female： 1.62% and 1.33%) and female breast cancer(1.06% and 1.00%) in 70 year-old group were increased significantly. ［Conclusion］ The disease burden attributed to T2DM is higher in tracheal， bronchus and lung cancer， colorectal cancer and female breast cancer. Except for liver cancer， the disease burden of cancers attributed to T2DM shows an increasing trend， among which pancreatic cancer， ovarian cancer and colorectal cancer are increased more rapidly， and the increasing trend in male is more rapidly than that in female. The disease burden attributable to T2DM of colorectal， bladder， pancreatic and ovarian cancers in the 25~49 year-old group and tracheal， bronchus and lung cancer and female breast cancer in the 70 year-old group should be paid more attention， and the cancer risk prevention and control for them should be strengthened. |
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