| 罗鹏飞,俞 浩,韩仁强,等.1990—2019年江苏省结直肠癌疾病负担与危险因素变化趋势研究[J].中国肿瘤,2022,31(12):967-974. |
| 1990—2019年江苏省结直肠癌疾病负担与危险因素变化趋势研究 |
| Study of Disease Burden and Related Risk Factors of Colorectal Cancer in Jiangsu Province， 1990—2019 |
| 投稿时间：2022-03-22 |
| DOI：10.11735/j.issn.1004-0242.2022.12.A005 |
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| 中文关键词: 结直肠癌 疾病负担 变化趋势 危险因素归因 江苏 |
| 英文关键词:colorectal cancer global burden of disease trend attribution of risk factors Jiangsu |
| 基金项目:中国消化道早癌医师共同成长计划科研项目（GTCZ-2020-JS-32-0002） |
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| 中文摘要: |
| 摘 要：［目的］ 分析江苏省1990—2019年间结直肠癌的疾病负担与主要危险因素的死亡归因情况。［方法］ 搜集江苏省慢性病及其危险因素监测、肿瘤登记、死因监测等疾病数据和社会人口学数据，通过GBD 2019平台测算结直肠癌的发病率、死亡率和死亡的危险因素归因，并计算其30年间标化发病率与死亡率的平均年度变化百分比（AAPC）。［结果］ 1990—2019年间，江苏省结直肠癌的标化发病率由10.72/10万增加至26.27/10万，AAPC为3.00%，标化死亡率由9.06/10万增加至11.77/10万，AAPC为0.90%，趋势变化均有统计学意义（P<0.05）。除女性人群结直肠癌的标化死亡率无显著变化外，其他分性别的标化发病率和标化死亡率 均显著增加。1990年和2019年，行为危险因素的死亡归因占全部死亡的构成分别为49.91%和49.51%，代谢危险因素的死亡归因构成分别为7.43%和12.33%，其中高体质指数（BMI）、吸烟、酒精使用、高血糖和高红肉饮食的死亡归因占比增加；低钙饮食和低牛奶饮食分别是1990年和2019年的首位死亡归因的饮食因素，归因占比分别为19.58%和19.14%。［结论］ 江苏省结直肠癌的发病和死亡负担在1990—2019年间显著增加。高BMI、烟草、酒精使用、高血糖和高红肉饮食的死亡归因占比逐渐升高，是今后应重点干预的危险因素。 |
| 英文摘要: |
| Abstract：［Purpose］ To analyze the disease burden and death attribution of major risk factors of colorectal cancer(CRC) in Jiangsu Province from 1990 to 2019. ［Methods］ The disease data including chronic diseases and their risk factors monitoring， cancer registration， death surveillance， and socio-demographic data were collected. The incidence and mortality rate of colorectal cancer and its death attribution of risk factors were estimated through the GBD 2019 platform and average annual percentage change(AAPC) of age-standardized rates were calculated. ［Results］ From 1990 to 2019， the age-standardized incidence rate by Segi’s population(ASIRW) of CRC in Jiangsu increased from 10.72/105 to 26.27/105， and its AAPC was 3.00%. The age-standardized mortality rate by Segi’s population (ASMRW) increased from 9.06/105 to 11.77/105， with a AAPC of 0.90%. All the changes above were statistically significant(P<0.05). The ASIRw for both gender and ASMRw for males were all significantly increased. Behavioral risk factors accounted for 49.91% and 49.51% of all deaths in 1990 and 2019， respectively， while metabolic risk factors accounted for 7.43% and 12.33% in 1990 and 2019， respectively. Among all risk factors， high body-mass index(BMI)， tobacco， alcohol use， high fasting plasma glucose and high intake of red meat were all with increasing attributable death percentages， and low intake of calcium and low intake of milk were the leading dietary factors for death in 1990 and 2019， accounting for 19.58% and 19.14%， respectively. ［Conclusion］ The incidence and mortality rates of CRC in Jiangsu increased significantly from 1990 to 2019. The proportion of death attributed to high BMI， tobacco， alcohol use， high fasting plasma glucose and high intake of red meat increased， and attention should be paid to those factors for the intervention in the future. |
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