| 孟 娜,俞 浩,罗鹏飞,等.1990—2019年江苏省居民食管癌疾病负担及其危险因素变化趋势分析[J].中国肿瘤,2023,32(3):184-190. |
| 1990—2019年江苏省居民食管癌疾病负担及其危险因素变化趋势分析 |
| Trends of Burden on Esophageal Cancer and Epidemiological Change of Related Risk Factors in Jiangsu Province from 1990 to 2019 |
| 投稿时间：2022-08-04 |
| DOI：10.11735/j.issn.1004-0242.2023.03.A004 |
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| 中文关键词: 食管癌 疾病负担 伤残调整寿命年 危险因素 江苏 |
| 英文关键词:esophageal cancer disease burden disability adjusted life year risk factors Jiangsu |
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| 中文摘要: |
| 摘 要：［目的］ 分析1990—2019年江苏省居民食管癌疾病负担及其危险因素变化趋势。［方法］ 利用2019年全球疾病负担研究结果，通过采用Joinpoint 4.9.0.0软件计算平均年度变化百分比（AAPC），分析1990—2019年江苏省居民食管癌发病率、死亡率、伤残调整寿命年（DALY）和过早死亡率的变化趋势。利用人群归因危险百分比估计食管癌不同危险因素的归因水平。［结果］ 1990—2019年间，江苏省居民食管癌标化发病率变化趋势差异无统计学意义（t=0.45，P=0.653），标化死亡率AAPC为-0.50%（t=-2.26，P=0.024），过早死亡率AAPC为-1.20%（t=-3.89，P＜0.001），标化DALY率AAPC为-0.93%（t=-4.04，P＜0.001），男女性整体变化趋势与全人群相似。食管癌DALY以过早死亡损失寿命年（YLL）为主，但伤残损失寿命年（YLD）的占比不断增加。男性食管癌疾病负担高于女性；随着年龄的增长，疾病负担呈现先升后降趋势，中老年人群疾病负担较重。江苏省食管癌的主要危险因素有吸烟、饮酒、饮食因素（低水果饮食、低蔬菜饮食）和高体质指数（BMI），其中归因于吸烟和饮酒的比例较大，男女性存在差异。［结论］ 1990—2019年，江苏省居民食管癌疾病负担整体呈下降趋势，但发病人数仍在上升，应将中老年男性人群作为重点防控人群，以戒烟限酒为主要措施，倡导健康生活方式，针对高危人群开展癌症早期筛查项目，从而进一步降低江苏省居民食管癌疾病负担。 |
| 英文摘要: |
| Abstract： ［Purpose］ To analyze the changing trends of disease burden and the risk factors of esophageal cancer in Jiangsu Province from 1990 to 2019. ［Methods］ Based on the results of the Global Burden of Disease Study 2019， trends in esophageal cancer incidence， mortality， disability-adjusted life years(DALY)， and premature mortality among residents of Jiangsu Province from 1990 to 2019 were analyzed by calculating the average annual percentage change(AAPC) using the Joinpoint 4.9.0.0 software. The attributing level of different risk factors of esophageal cancer was estimated by population attributing risk percent. ［Results］ From 1990 to 2019， the annual standardized incidence rates of esophageal cancer in Jiangsu Province did not show significant changes(t=0.45， P=0.653)， the AAPC for standardized mortality was -0.50%(t=-2.26， P=0.024)， the AAPC for premature mortality was -1.20%(t=-3.89， P<0.001)， and the AAPC for standardized DALY rate was -0.93%(t=-4.04， P<0.001)， the trend was similar for men and women as a whole. The years of life lost(YLL） was the main component of DALY caused by esophageal cancer，but the proportion of years lived with disability (YLD) in DALY was increasing. The disease burden of esophageal cancer was higher in male than that in female. With the increase in age， the burden of disease showed an upward trend followed by a downward trend， and the burden of disease was the highest in the middle and old aged population. The main risk factors for esophageal cancer in Jiangsu Province were tobacco， alcohol use， dietary factors(diet low in fruits， diet low in vegetables)， and high body mass index(BMI)， among which smoking and alcohol use accounted for a large proportion， and there were differences between men and women. ［Conclusion］ From 1990 to 2019， the overall disease burden of esophageal cancer in Jiangsu Province is on the decline， but the incidence is still on the rise， prevention and control should focus on middle and old aged men. To further reduce the disease burden of esophageal cancer in Jiangsu Province， it should take tobacco control and alcohol restriction as the priority， and to advocate a healthy lifestyle and carry out screening programs for high-risk groups are also necessary. |
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