| 徐 轲,吴华鑫,林超男.肿瘤细胞内PD-L1作用相关研究进展[J].中国肿瘤,2023,32(9):714-722. |
| 肿瘤细胞内PD-L1作用相关研究进展 |
| Research Progress on Roles of Intracellular PD-L1 in Tumor Cells |
| 投稿时间：2023-06-13 |
| DOI：10.11735/j.issn.1004-0242.2023.09.A010 |
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| 中文关键词: 胞内PD-L1 细胞自噬 DNA损伤修复 肿瘤转移 |
| 英文关键词:intracellular PD-L1 autophagy DNA damage repair tumor metastasis |
| 基金项目:国家自然科学基金（81672915）；广东省自然科学基金（2022A1515010515） |
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| 中文摘要: |
| 摘 要：程序性细胞死亡蛋白1(PD-1)及其配体PD-L1是重要的免疫检查点蛋白，肿瘤细胞膜上的PD-L1与T细胞上的PD-1结合以逃避免疫监视。靶向PD-L1/PD-1的免疫疗法在多种肿瘤的治疗中显示出了显著的临床效果，遗憾的是只有一部分患者实现了持久反应。最新研究表明，PD-L1可定位于肿瘤细胞内，发挥着非免疫检查点功能，广泛参与肿瘤细胞的多种恶性表型。全文总结了肿瘤细胞内PD-L1作用的相关研究进展，从PD-L1胞内定位的调控，以及胞内PD-L1与DNA损伤修复、细胞自噬、细胞凋亡、肿瘤转移的关系，论述了胞内PD-L1与肿瘤细胞恶性表型的关系。最后，介绍了靶向胞内PD-L1的策略方法，为靶向PD-L1的癌症治疗提供思路。 |
| 英文摘要: |
| Abstract： Programmed cell death protein 1(PD-1) and its ligand PD-L1 are important immune checkpoint proteins. In tumor cells， PD-L1 is mainly located on cell membranes， which binds to PD-1 on T cells to evade immune surveillance. Immunotherapies targeting PD-L1/PD-1 have shown significant results in the treatment of various tumors， but unfortunately， only a subset of patients have achieved a consistent response. Latest studies have shown that PD-L1 can be also localized in tumor cells(intracellular PD-L1)， playing a non-immune checkpoint function， and involving in various malignant phenotypes of tumor cells. This paper reviews the research progress on the role of intracellular PD-L1(intra-PD-L1) in tumor cells； discusses the relationship between intra-PD-L1 and the malignant phenotype of tumor cells， focusing on the regulation of intracellular localization of PD-L1， the relationship of intra-PD-L1 with DNA damage repair， autophagy， apoptosis and tumor metastasis， as well as the strategy of targeting intra-PD-L1 for clinical cancer treatment. |
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