| 范文凭,林 琳,刘江美,等.基于GBD数据分析1990—2019年中国恶性肿瘤疾病负担趋势[J].中国肿瘤,2024,33(1):20-26. |
| 基于GBD数据分析1990—2019年中国恶性肿瘤疾病负担趋势 |
| Trend Analysis of Disease Burden of Malignant Tumors in China Based on GBD Data， 1990—2019 |
| 投稿时间：2023-11-11 |
| DOI：10.11735/j.issn.1004-0242.2024.01.A004 |
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| 中文关键词: 恶性肿瘤 发病率 死亡率 变化趋势 疾病负担 中国 |
| 英文关键词:malignant tumors incidence rate mortality rate change trend burden of disease China |
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| 摘要点击次数: 249 |
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| 中文摘要: |
| 摘 要：［目的］ 分析1990—2019年中国恶性肿瘤的疾病负担及其变化趋势。［方法］ 从2019全球疾病负担研究（GBD 2019）数据库中提取1990—2019年中国恶性肿瘤发病率和死亡率数据，采用2010年全国人口普查数据标化恶性肿瘤发病率和死亡率，使用Joinpoint 5.0软件分析1990—2019年中国恶性肿瘤标化发病率和死亡率的变化趋势。［结果］ 1990—2019年中国恶性肿瘤的发病率从148.84/10万（95%UI：131.71/10万~166.38/10万）增长到334.53/10万（95%UI：289.07/10万~385.94/10万）；标化发病率从197.09/10万（95%UI：175.26/10万~219.71/10万）增长到244.75/10万（95%UI：212.12/10万~281.05/10万）。1990—2019年中国全部恶性肿瘤死亡率从123.11/10万（95%UI：108.85/10万~137.27/10万）增长到190.66/10万（95%UI：162.49/10万~220.23/10万）；标化死亡率从173.78/10万（95%UI：153.91/10万~192.72/10万）减少到140.66/10万（95%UI：120.39/10万~161.58/10万）。2019年标化发病率排名前5位的恶性肿瘤分别为肺癌、胃癌、结直肠癌、乳腺癌和非黑色素瘤皮肤癌。胃癌的标化发病率整体上呈现波动下降趋势，肺癌、结直肠癌、乳腺癌、非黑色素瘤皮肤癌的标化发病率整体上均呈现波动上升趋势（P均<0.05）。2019年标化死亡率排名前5位的恶性肿瘤分别为肺癌、胃癌、结直肠癌、食管癌和肝癌。肺癌和结直肠癌的标化死亡率整体上呈现波动上升趋势；食管癌、胃癌和肝癌的标化死亡率整体上呈现波动下降趋势（P均<0.05）。［结论］ 1990—2019年中国恶性肿瘤的标化发病率呈现上升趋势，标化死亡率呈现下降趋势。仍需采取更多具有针对性的三级预防措施，以降低恶性肿瘤的疾病负担。 |
| 英文摘要: |
| Abstract： ［Purpose］ To analyse the disease burden of malignant tumors and its changing trends in China from 1990 to 2019. ［Methods］ Data of malignant tumor incidence and mortality in China from 1990 to 2019 were extracted from the Global Burden of Disease Study 2019 (GBD 2019)， and the incidence and mortality rates of malignant tumors were standardized using data from the 2010 national census， and the data were analyzed using Joinpoint 5.0 software to describe the trends of malignant tumors in China from 1990 to 2019. ［Results］ The crude incidence rate of malignant tumors in China increased from 148.84/105(95%UI：131.71/105~166.38/105) in 1990 to 334.53/105 (95%UI：289.07/105~385.94/105) in 2019； the standardized incidence rate increased from 197.09/105 (95%UI：175.26/105~219.71/105) to 244.75/105(95%UI：212.12/105~281.05/105). The crude mortality rate of malignant tumors in China increased from 123.11/105(95%UI：108.85/105~137.27/105) in 1990 to 190.66/105(95%UI：162.49/105~220.23/105) in 2019； the standardized mortality rate decreased from 173.78/105(95%UI：153.91/105~192.72/105) to 140.66/105(95%UI：120.39/105~161.58/105). The top five malignant tumors of high incidence rate in 2019 were lung cancer， stomach cancer， colorectal cancer， breast cancer and non-melanoma skin cancer. The standardized incidence rate of stomach cancer showed an overall fluctuating downward trend； while that of lung cancer， colorectal cancer， breast cancer and non-melanoma skin cancer showed an overall fluctuating upward trend（all P<0.05）. The top five malignant tumors of high standardized mortality rate in 2019 were lung cancer， stomach cancer， colorectal cancer， esophageal cancer and liver cancer. The standardized mortality rates of lung cancer and colorectal cancer showed fluctuating upward trends； while that of esophageal cancer， stomach cancer and liver cancer showed fluctuating downward trends（all P<0.05）. ［Conclusion］ From 1990 to 2019， the standar-dized incidence rate of malignant tumors in China showed an increasing trend， and the standar-dized mortality rate showed a decreasing trend. More targeted tertiary prevention measures are still needed to reduce the disease burden of malignant tumors in China. |
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