| 张克博,刘玉琴,丁高恒,等.2019年甘肃省肿瘤登记地区胆囊癌流行特征及2010—2019年变化趋势分析[J].中国肿瘤,2024,33(2):96-102. |
| 2019年甘肃省肿瘤登记地区胆囊癌流行特征及2010—2019年变化趋势分析 |
| Epidemiological Characteristics of Gallbladder Cancer in Cancer Registration Areas of Gansu Province in 2019 and Trend from 2010 to 2019 |
| 投稿时间：2023-11-07 |
| DOI：10.11735/j.issn.1004-0242.2024.02.A003 |
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| 中文关键词: 胆囊癌 发病率 死亡率 甘肃 |
| 英文关键词:gallbladder cancer incidence rate mortality rate Gansu |
| 基金项目: |
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| 中文摘要: |
| 摘 要：［目的］ 分析甘肃省肿瘤登记地区2019年胆囊癌发病和死亡流行特征及2010—2019年变化趋势。［方法］ 收集甘肃省23个肿瘤登记点上报的数据作为样本数据，计算胆囊癌粗发病率(死亡率)、标化率(中国人口标化率，简称中标率；世界人口标化率，简称世标率)、0～74岁累积率等，用Joinpoint 5.0.2计算年度变化百分比(annual percentage change，APC)。［结果］ 2019年甘肃省肿瘤登记地区胆囊癌新发病例521例，粗发病率为5.62/10万，中标发病率为3.59/10万；死亡病例303例，粗死亡率为3.27/10万，中标死亡率为2.01/10万。2010—2019年甘肃省肿瘤登记地区胆囊癌新发病例1 361例，粗发病率为4.59/10万(男性3.72/10万，女性5.52/10万)，中标发病率为3.68/10万；死亡病例849例，粗死亡率为2.96/10万(男性2.33/10万，女性3.62/10万)，中标死亡率为2.45/10万。城市地区中标发病率(3.78/10万)和中标死亡率(2.63/10万)均高于农村地区中标发病率(3.41/10万)和中标死亡率(1.79/10万)。胆囊癌中标发病率和死亡率随着年龄的增长呈上升趋势，在75~79岁年龄组达到峰值，峰值有年轻化趋势。甘肃省2010—2019年农村地区胆囊癌中标发病率呈上升趋势(APC=8.41%，P=0.04)，城市地区中标发病率、死亡率变化差异无统计学意义 (P均>0.05)。［结论］ 胆囊癌已成为甘肃省较为常见的恶性肿瘤之一，其农村地区发病率呈现上升趋势，是今后防治工作的重点。城市地区中老年女性居民为胆囊癌防治的重点人群，应针对其开展“三早”工作。 |
| 英文摘要: |
| Abstract： ［Purpose］ To analyze the incidence and mortality of gallbladder cancer in cancer regi-stration areas of Gansu Province in 2019 and its trend from 2010 to 2019. ［Methods］ Cancer incidence and death data were collected from 23 cancer registries in Gansu Province. The crude incidence and mortality rates， age-standardized incidence/mortality rates of Chinese standard population(ASIRC， ASMRC) and world standard population(ASIRW， ASMRW)， and cumulative rate(0~74 years old) were calculated. The annual percentage change(APC) was calculated with Joinpoint 5.0.2. ［Results］ There were 521 new cases of gallbladder cancer in Gansu cancer registration areas in 2019， and the crude incidence was 5.62/105 with an ASIRC of 3.59/105. There were 303 deaths of gallbladder cancer in 2019, and the crude mortaliby was 3.27/105 with an ASMRC of 2.01/105. From 2010 to 2019， there were 1 361 new cases of gallbladder cancer reported in the Gansu cancer registration areas， and the crude incidence was 4.59/105(3.72/105 in male， 5.52/105 in female) with an ASIRC of 3.68/105. There were 849 deaths of gallbladder cancer were reported from 2010 to 2019， and the crude mortality rate was 2.96/105(2.33/105 in male， 3.62/105 in female) with an ASMRC of 2.45/105. The ASIRC and ASMRC in urban areas were significantly higher than those in rural areas(3.78/105 vs 3.41/105 and 2.63/105 vs 1.79/105). The incidence and mortality of gallbladder cancer increased with the age， peaking at the age group of 75~79 years old. The ASIRC in rural areas from 2010 to 2019 showed an increasing trend(APC=8.41%， P=0.04) ； while there was no significant change in ASIRC and ASMRC in urban areas from 2010 to 2019(P>0.05). ［Conclusion］ Gallbladder cancer has become one of the common malignant tumors in Gansu Province， and the incidence in rural areas showed an increasing trend during 2010 to 2019. Middle-aged and elderly women in urban areas are the key groups for the prevention and control of gallbladder cancer， so early detection， early diagnosis and early treatment should be carried out for them. |
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