| 王 军,陈永胜,樊 健,等.1972—2021年江苏省启东市非霍奇金淋巴瘤发病趋势分析[J].中国肿瘤,2025,34(4):297-303. |
| 1972—2021年江苏省启东市非霍奇金淋巴瘤发病趋势分析 |
| Trend of Non-Hodgkin’s Lymphoma Incidence in Qidong City of Jiangsu Province from 1972 to 2021 |
| 投稿时间：2024-05-28 |
| DOI：10.11735/j.issn.1004-0242.2025.04.A007 |
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| 中文关键词: 非霍奇金淋巴瘤 发病 年龄-时期-队列模型 趋势 江苏 |
| 英文关键词:non-Hodgkin’s lymphoma incidence age-period-cohort model trend Jiangsu |
| 基金项目:南通市“十四五”科教强卫工程（通卫科技〔2021〕15号）；南通市卫生健康委员会科研课题（MS2023121） |
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| 中文摘要: |
| 摘 要：［目的］ 分析江苏省启东市1972—2021年非霍奇金淋巴瘤发病流行趋势。［方法］ 提取启东市肿瘤登记处1972—2021年非霍奇金淋巴瘤发病登记资料，计算粗发病率、中国人口标准化发病率（中标率）、世界人口标准化发病率（世标率）、35~64岁截缩发病率和0~74岁累积发病率等。年龄-时期-队列模型分析非霍奇金淋巴瘤发病率的年龄、时期和队列效应；采用Joinpoint 4.9.1.0软件进行趋势分析，计算非霍奇金淋巴瘤发病率的平均年度变化百分比（average annual percentage change，AAPC）。［结果］ 1972—2021年启东市非霍奇金淋巴瘤共计发病2 681例，粗发病率为4.78/10万，中标发病率为3.35/10万，世标发病率为3.30/10万，35~64岁截缩发病率为5.20/10万，0~74岁累积发病率为0.37%。男性发病1 589例，粗发病率、中标率、世标率分别为5.75/10万、4.19/10万、4.14/10万；女性发病1 092例，粗发病率、中标率、世标率分别为3.84/10万、2.60/10万、2.54/10万。年龄-时期-队列分析显示，非霍奇金淋巴瘤发病率的净漂移值为1.65（95%CI：1.19~2.11），年龄、时期和队列效应均为非霍奇金淋巴瘤发病率的重要影响因素，差异均有统计学意义（P均<0.05）。1972—2021年启东市非霍奇金淋巴瘤中标率男女合计、男性和女性的AAPC分别为1.71%（95%CI：0.88%~2.54%，t=4.07）、1.62%（95%CI：1.14%~2.11%，t=6.77）和2.01%（95%CI：0.77%~3.26%，t=3.19），上升趋势显著，差异均有统计学意义（P 均<0.01）。 ［结论］ 启东市非霍奇金淋巴瘤50年来标化发病率整体呈现上升趋势，男性发病率高于女性，老年人群发病率高，应重视老年人群和男性非霍奇金淋巴瘤的防治和健康教育。 |
| 英文摘要: |
| Abstract： ［Purpose］ To analyze the trend of non-Hodgkin’s lymphoma incidence in Qidong City of Jiangsu Province from 1972 to 2021. ［Methods］ The data of non-Hodgkin’s lymphoma incidence collected from Qidong Cancer Registry from 1972 to 2021 were extracted. The crude incidence rate (CR)， age-standardized rate by Chinese standard population (ASRC) and by world standard population (ASRW)， truncated incidence rate (35~64 years old) and cumulative incidence rate (0~74 years old) were calculated. The age-period-cohort model was used to analyze the age， period， and cohort effects of incidence in non-Hodgkin’s lymphoma. Joinpoint 4.9.1.0 software was used to calculate the average annual percentage change (AAPC) of non-Hodgkin’s lymphoma incidence for trend analysis. ［Results］ There were a total of 2 681 cases of non-Hodgkin’s lymphoma reported in Qidong from 1972 to 2021. The CR， ASRC， ASRW， the truncated incidence (35~64 years old) rate and cumulative incidence rate (0~74 years old) were 4.78/105， 3.35/105， 3.30/105， 5.20/105 and 0.37%， respectively. There were 1 589 male cases， with CR， ASRC and ASRW of 5.75/105， 4.19/105 and 4.14/105， respectively； and there were 1 092 female cases， with CR， ASRC and ASRW of 3.84/105， 2.60/105 and 2.54/105， respectively. Age-period-cohort analysis showed that the net drift value of non-Hodgkin’s lymphoma incidence was 1.65 (95%CI： 1.19~2.11)， and age， period and cohort effects were all important influencing factors of non-Hodgkin’s lymphoma incidence rate (all P<0.05). The AAPCs for both sex， male and female of ASRC of non-Hodgkin’s lymphoma in Qidong from 1972 to 2021 were 1.71% (95%CI： 0.88%~2.54%， t=4.07)， 1.62% (95%CI： 1.14%~2.11%， t=6.77)， and 2.01% (95%CI： 0.77%~3.26%， t=3.19)， respectively，with a significant upward trend， and the differences were statistically significant (all P<0.01). ［Conclusion］ Non-Hodgkin’s lymphoma in Qidong City shows an overall increasing trend in the age-standardized incidence over the past 50 years， with a higher incidence in male and in the elderly population. |
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