| 罗 辉,杨成梁,葛 红.中国FLASH放射疗法快速发展的机遇和挑战[J].中国肿瘤,2025,34(4):326-330. |
| 中国FLASH放射疗法快速发展的机遇和挑战 |
| Opportunities and Challenges for the Rapid Development of FLASH Radiotherapy in China |
| 投稿时间：2024-11-12 |
| DOI：10.11735/j.issn.1004-0242.2025.04.A011 |
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| 中文关键词: FLASH放疗 临床研究 机遇 挑战 中国 |
| 英文关键词:FLASH radiotherapy clinical research opportunity challenges China |
| 基金项目: |
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| 中文摘要: |
| 摘 要：近年来，FLASH放射疗法（FLASH radiotherapy，FLASH-RT）作为国际上一种尖端放疗技术，理论研究和临床试验发展迅速。FLASH-RT能够在极短时间（通常≤500 ms）内实施超高剂量率（平均剂量率≥40 Gy/s，瞬时剂量率≥100 Gy/s）照射，在保持相同肿瘤控制率的前提下，正常组织损伤小于同剂量的常规剂量率照射，即FLASH效应。FLASH-RT具有独特的放射生物学优势，是目前国际放射肿瘤学界的前沿领域。中国在FLASH-RT的研发和临床试验方面取得了飞跃式的进展，成为重要的参与者。全文对中国FLASH-RT面临的新挑战和机遇进行了全面的阐述。 |
| 英文摘要: |
| Abstract： In recent years， FLASH radiotherapy(FLASH-RT)， as a cutting-edge radiotherapy technology， has developed rapidly in basic research and clinical trials. FLASH-RT can deliver ultra-high dose rate(average dose rate ≥ 40 Gy/s， instantaneous dose rate ≥ 100 Gy/s) irradiation in a very short time(usually ≤ 500 ms). Under the premise of maintaining equivalent tumor control rates， the normal tissue injury is less than that of conventional irradiation at the same dose， that is known as the FLASH effect. FLASH-RT has unique advantages and is currently the frontier field of radiation oncology. The research and development of FLASH-RT have progressed rapidly in China， this paper elucidated the new challenges and opportunities of FLASH-RT in China. |
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