丁璐璐,张永辉,徐源佑,等.1972—2021年江苏省启东市脑及中枢神经系统肿瘤发病流行趋势[J].中国肿瘤,2025,34(6):471-476.
1972—2021年江苏省启东市脑及中枢神经系统肿瘤发病流行趋势
Incidence Trend of Brain and Other Central Nervous System Tumors in Qidong City of Jiangsu Province from 1972 to 2021
投稿时间:2024-08-23  
DOI:10.11735/j.issn.1004-0242.2025.06.A007
中文关键词:  脑及中枢神经系统肿瘤  发病率  趋势  年龄-时期-队列模型  江苏
英文关键词:brain tumor  incidence  trend  age-period-cohort model  Jiangsu
基金项目:2023年度南通市卫生健康委科研项目(MS2023121);南通市“十四五”科教强卫工程(通卫科技〔2021〕15号)
作者单位
丁璐璐 启东市人民医院/启东肝癌防治研究所/南通大学附属启东医院 
张永辉 启东市人民医院/启东肝癌防治研究所/南通大学附属启东医院 
徐源佑 启东市人民医院/启东肝癌防治研究所/南通大学附属启东医院 
陈永胜 启东市人民医院/启东肝癌防治研究所/南通大学附属启东医院 
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中文摘要:
      摘 要: [目的] 分析江苏省启东市1972—2021年全人群脑及中枢神经系统肿瘤(以下简称脑肿瘤)发病变化趋势,评估其年龄、时期和队列效应。[方法] 从启东市肿瘤登记病例数据库中提取1972—2021年脑肿瘤发病登记资料,计算粗发病率、中国人口标化率(简称中标率)、世界人口标化率(简称世标率)和平均年度变化百分比(average annual percentage change,AAPC)。中标率和世标率分别采用2000年全国普查人口和Segi世界标准人口年龄构成进行计算。采用年龄-时期-队列模型分析启东市1972—2021年脑肿瘤发病率的年龄、时期和队列效应。[结果] 启东市1972—2021年共计发生脑肿瘤2 801例(男性1 475例,女性1 326例)。粗发病率从1972—1976年的1.81/10万上升至2017—2021年的9.28/10万;中标率从1972—1976年的2.07/10万上升至2017—2021年的4.96/10万;世标率从1972—1976年的2.00/10万上升至2017—2021年的4.98/10万。1972—2021年脑肿瘤粗发病率、中标率和世标率的AAPC分别为3.97%(男性3.53%、女性4.37%)、2.02%(男性1.66%、女性2.24%)、2.06%(男性1.63%、女性2.24%)(P均<0.001)。脑肿瘤发病风险的年龄效应、时期效应和出生队列效应趋势变化差异均具有统计学意义(P均<0.05)。年龄效应表现为脑肿瘤发病率随着年龄增长呈上升趋势,从45~49岁组开始上升速度明显,至75~79岁组达到峰值25.84/10万(95%CI:21.17/10万~31.53/10万)。时期效应以1992—1996年组为参照组,近期发病风险高于研究早期,2012—2016年达到最高,RR为1.64(95%CI:1.38~1.95)。出生队列效应以1952—1956年出生为参照组,最高峰在2017—2021年,RR为11.17(95%CI:4.26~29.26)。[结论] 1972—2021年启东市脑肿瘤发病率呈上升趋势,年龄、时期和队列均是影响启东脑肿瘤发病的主要因素,中老年人群应是脑肿瘤防控重点关注对象。
英文摘要:
      Abstract: [Purpose] To analyze the incidence trend and age, period, cohort effects of brain and other central nervous system tumors (brain tumor) in Qidong City of Jiangsu Province from 1972 to 2021. [Methods] The incidence data of brain tumor from 1972 to 2021 were collected from the Qidong cancer registry database. The crude incidence rate (CR), age-standardized rate by Chinese standard population (ASRC), age-standardized rate by world standard population (ASRW) and average annual percentage change (AAPC) were calculated. The age-period-cohort (APC) model was used to analyze the age, period, and cohort effects of brain tumor incidence in Qidong City from 1972 to 2021. [Results] A total of 2 801 cases of brain tumor occurred in Qidong City from 1972 to 2021, including 1 475 male cases and 1 326 female cases. From 1972—1976 to 2017—2021, the CR increased from 1.81/105 to 9.28/105, the ASRC increased from 2.07/105 to 4.96/105, and ASRW increased from 2.00/105 to 4.98/105. From 1972 to 2021 the AAPC of CR, ASRC and ASRW were 3.97% (3.53% for male and 4.37% for female), 2.02% (1.66% for male and 2.24% for female) and 2.06% (1.63% for male and 2.24% for female) (all P<0.001). The Wald’s Chi-square test of the APC model showed that there were significant differences in the trends of age, period and birth cohort effect of brain tumor risk (all P<0.05). The age effect showed that the incidence of brain tumor increased with age, starting from the age group of 45~49 years old and reaching a peak of 25.84/105 in age group of 75~79 years old (95%CI: 21.17/105~31.53/105). The period effect showed that the risk of recent period was higher than that in the early period using 1992—1996 period as the reference, reaching the highest in 2012—2016 (RR=1.64, 95%CI: 1.38~1.95). The birth cohort effect showed that the highest risk was in 2017—2021 births cohort (RR=11.17, 95%CI:4.26~29.26) using 1952—1956 birth cohort as the reference. [Conclusion] The incidence of brain tumor in Qidong City has been rising; and age, period and cohort are the main influencing factors, suggesting that the middle-aged and elderly population should be the focus of brain tumor prevention and control.
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