| 陈泉玮,孙元栋,龚小龙,等.热消融在肝细胞癌治疗中的应用及研究进展[J].中国肿瘤,2025,34(7):574-581. |
| 热消融在肝细胞癌治疗中的应用及研究进展 |
| Applications and Advances of Thermal Ablation in Hepatocellular Carcinoma |
| 投稿时间：2025-01-06 |
| DOI：10.11735/j.issn.1004-0242.2025.07.A011 |
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| 中文关键词: 肝细胞癌 热消融 完全消融 联合治疗 |
| 英文关键词:hepatocellular carcinoma thermal ablation complete ablation combined therapy |
| 基金项目:国家自然科学基金（8227071910）；山东省自然科学基金（ZR2021MH060） |
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| 摘要点击次数: 67 |
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| 中文摘要: |
| 摘 要：肝癌全球疾病负担严重。其中，肝细胞癌（hepatocellular carcinoma，HCC）作为原发性肝癌的主要病理类型，约占其发病总数的90%。热消融作为一种微创治疗手段，对肝功能影响小、创伤小，是不适合手术切除治疗的早期HCC患者的一线治疗选择。然而，临床数据显示，HCC 患者经热消融治疗后 5 年复发率高达 50%~70%，其中消融不完全是导致复发的核心因素。因此，探索并优化完全消融策略，成为提升HCC热消融疗效及患者长期生存率的关键方向。全文系统综述热消融在HCC治疗中的应用现状，并重点探讨实现完全消融的关键技术与策略，以期为临床实践中提高HCC热消融治疗的完全消融率、制定个体化诊疗方案提供理论依据与技术参考 |
| 英文摘要: |
| Abstract： Liver cancer imposes a substantial global disease burden. Hepatocellular carcinoma （HCC）， as the primary pathological type of primary liver cancer， accounts for approximately 90% of all cases. As a minimally invasive treatment， thermal ablation causes minimal impact on liver function and trauma， serving as the first-line treatment option for early-stage HCC patients unsuitable for surgical resection. However， clinical data indicate that 5-year recurrence rate of HCC patients after thermal ablation treatment is as high as 50%~70%， and incomplete ablation remains a core factor leading to recurrence. Therefore， exploring and optimizing complete ablation strategies has become a critical direction for improving the efficacy of thermal ablation in HCC and enhancing long-term survival rates of patients. This paper systematically reviews the current applications of thermal ablation in HCC treatment and focuses on discussing key technologies and strategies for achieving complete ablation， with the aim of providing theoretical foundations and technical references for improving the complete ablation rate of thermal ablation in clinical practice and formulating personalized diagnosis and treatment plans. |
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