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| CD39-CD73介导的腺苷信号通路在胃癌免疫调控中的作用及研究进展 |
| The Role and Research Progress of the CD39-CD73-mediated Adenosine Signaling Pathway in the Immune Regulation of Gastric Cancer |
| 投稿时间：2023-10-09 修订日期：2023-12-18 |
| DOI： |
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| 中文关键词: 胃癌 CD39 CD73 腺苷 免疫疗法 |
| 英文关键词:gastric cancer CD39 CD73 adenosine immunotherapy |
| 基金项目:中国科学院基础医学与肿瘤研究所科研人才启动经费 |
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| 中文摘要: |
| 胃癌作为最常见的上消化道恶性肿瘤之一,由于早期阶段缺乏明显特异性症状,类似于慢性胃炎、功能性消化不良等疾病的症状,胃癌患者在初诊时大多已进展至局部晚期或全身转移,错过了最佳治疗时机。晚期胃癌的治疗手段主要为化疗、靶向治疗及近年来出现的免疫治疗,但以程序性死亡受体1(PD-1)抗体为代表的免疫检查点抑制剂(ICIs)仅能改善部分晚期患者,临床疗效受限。目前,基于腺苷信号通路在癌症中作用的研究日益受到重视,有望成为肿瘤治疗的另一潜在靶点。本文就腺苷信号通路在胃癌免疫调控中的作用及研究进展作一综述。 |
| 英文摘要: |
| As one of the most common malignant tumors in the upper digestive tract, gastric cancer is often diagnosed at an advanced stage due to the lack of specific symptoms in the early stages, which is similar to those of diseases such as chronic gastritis and functional dyspepsia. The main treatment for advanced gastric cancer includes chemotherapy, targeted therapy, and more recently, immunotherapy. However, immunotherapy with immune checkpoint inhibitors (ICIs) such as programmed cell death protein 1 (PD-1) antibodies can only improve the condition of some patients with limited clinical efficacy. Recently the adenosine signaling pathway in cancer has gained increasing attention and may become another potential target for tumor treatment. This article provides a review of the role of adenosine signaling pathway in immune regulation in gastric cancer. |
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