阴道微生物群和宫颈癌关系研究进展
Advances in the study of the relationship between vaginal cc and cervical cancer
投稿时间:2024-02-20  修订日期:2024-03-27
DOI:
中文关键词:  阴道微生物  宫颈癌  人乳头瘤病毒
英文关键词:vaginal microbiota  cervical cancer  human papillomavirus (HPV)
基金项目:
作者单位邮编
冯涛 浙江中医药大学附属第二临床医学院 310022
徐小仙 浙江省肿瘤医院 
楼寒梅* 浙江省肿瘤医院 310022
摘要点击次数: 62
全文下载次数: 10
中文摘要:
      阴道微生物组是阴道中独特的微生物集合,对宫颈、阴道健康至关重要。最近的研究表明,以乳杆菌减少和有害细菌过度生长为特征的阴道微生物群会引发免疫和上皮稳态失调的炎症微环境,可能会进一步加剧人乳头瘤病毒(Human Papilloma Virus,HPV)持续感染和宫颈分化异常,推动宫颈癌变。全文针对阴道微生物组与HPV感染相关的宫颈癌发生发展的关系,以及益生菌群对宫颈疾病尤其宫颈癌的预防及治疗的潜力进行综述。
英文摘要:
      The vaginal microbiome is a unique collection of microorganisms in the cervicovaginal area that is critical to cervical health. Recent studies have shown that disruption of the vaginal microbiome, characterised by Lactobacillus reduction and harmful bacterial overgrowth, may exacerbate persistent HPV infection and cervical differentiation abnormalities, which is a prominent global health problem driving the cervical cancer. The whole paper is based on the influence of vaginal microbiome on the development of cervical cancer, and further elaborates on the review of probiotic flora for the prevention and treatment of cervical diseases, especially cervical cancer.
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