Purpose To evaluate the effectiveness and benefit of colorectal cancer screening in Changsha city from 2023 to 2024. Methods The data and cost data of colorectal cancer screening in Changsha were collected, and the high-risk rate, colonoscopy compliance and lesion detection rate were calculated. The cost-effectiveness and cost-benefit evaluation methods of screening programs were evaluated. Results 61957 people were recruited for colorectal cancer screening in Changsha, and 17322(27.96%) were at high risk,1133(8.01%) were positive for gene detection .The compliance rate was 61.25%. The detection rates of precancerous lesions and non-adenomatous polyps were 1.59% , 42.51% and 22.48% respectively. The total cost of screening in this study was 3.671 million yuan, and the total benefit was 12.8528 million yuan. The cost-benefit ratio was 1:3.50. The Early Detection Cost Index (EDCI) for screening different types of lesions varies, ranging from 0.10 to 2.47, all of which were less than 5. Conclusion The colorectal cance screening in Changsha city from 2023 to 2024 has good efficacy and benefit. and has played a promoting role in the early detection, diagnosis, and treatment of colorectal cancer in Changsha |