|
| 肿瘤力学微环境在乳腺癌侵袭转移中的作用及诊疗意义研究进展 |
| Research Progress on the Role of Tumor Mechanical Microenvironment in Breast Cancer Invasion and Metastasis and Its Clinical Implications |
| 投稿时间：2026-04-22 修订日期：2026-07-24 |
| DOI： |
|
 |
| 中文关键词: 乳腺癌 肿瘤力学微环境 侵袭转移 细胞外基质 机械转导 风险分层 干预靶点 |
| 英文关键词:breast cancer tumor mechanical microenvironment invasion and metastasis extracellular matrix mechan transduction risk stratification intervention targets |
| 基金项目:MFAPI K324乳酰化调控乳腺癌发生发展及湛江弓果藤抗乳腺癌研究 |
|
| 摘要点击次数: 32 |
| 全文下载次数: 0 |
| 中文摘要: |
| 乳腺癌侵袭转移是影响复发风险和长期预后的关键环节,现有分子分型和常规病理指标虽可提供重要分层信息,但对不同患者癌症侵袭转移异质性的解释仍有限。肿瘤力学微环境涉及细胞外基质沉积与重塑、基质硬化、黏附斑-细胞骨架重构等细胞核力学,以及血管、免疫和远端微环境塑形等过程,共同参与了乳腺癌侵袭转移的多个步骤。现有乳腺癌相关研究证据提示,上述力学异常不仅影响侵袭前沿的形成、局部突破和播散,还可能与影像硬度读数、胶原结构特征、ECM分子信号等相关,可以为乳腺癌转移风险分层和联合治疗设计提供一定的补充线索。在干预层面,ECM去硬化、整合素/黏附斑激酶(FAK)轴阻断、Yes相关蛋白/转录辅激活因子(YAP/TAZ)调控及癌相关成纤维细胞-细胞外基质(CAF-ECM)重塑的多维度干预显示出一定潜在价值。总体而言,肿瘤力学微环境有潜力成为解释乳腺癌侵袭转移异质性、优化复合分层和筛选潜在干预靶点的补充维度,其临床应用仍需进一步前瞻性研究、多中心标准化验证。 |
| 英文摘要: |
| Breast cancer invasion and metastasis are key processes affecting recurrence risk and long-term prognosis. Although current molecular subtyping and conventional pathological indicators provide important stratification information, their ability to explain the heterogeneity of invasive and metastatic behavior across patients remains limited. The tumor mechanical microenvironment involves extracellular matrix deposition and remodeling, matrix stiffening, focal-adhesion-cytoskeletal remodeling, nuclear mechanics, and remodeling of vascular, immune, and distant microenvironments, which together may participate in multiple steps of breast cancer invasion and metastasis. Current breast-cancer-related evidence suggests that these mechanical abnormalities may influence invasive-front formation, local tissue breach, and dissemination, and may also be associated with imaging-derived stiffness readouts, collagen structural features, and extracellular-matrix molecular signals, thereby providing complementary clues for metastatic risk stratification and combination-therapy design. At the interventional level, multidimensional strategies targeting extracellular matrix softening, blockade of the integrin/focal adhesion kinase axis, modulation of Yes-associated protein/transcriptional coactivator with PDZ-binding motif (YAP/TAZ) signaling, and regulation of cancer-associated fibroblast-extracellular matrix remodeling have shown potential value. Overall, the tumor mechanical microenvironment may serve as a supplementary dimension for explaining heterogeneity in breast cancer invasion and metastasis, optimizing composite stratification, and identifying candidate intervention targets. Its clinical application, however, still requires further prospective studies and multicenter standardized validation. |
|
在线阅读
查看/发表评论 下载PDF阅读器 |
|
|
|