| [Purpose] To analyze the current status of leukemia incidence and mortality in cancer registration areas of Zhejiang Province in 2021, and to examine the temporal trends from 2000 to 2021.[Methods]Data on leukemia incidence, mortality, and population were collected from 22 cancer registration areas in Zhejiang Province. Uniform quality control standards were applied. Crude incidence rate, crude mortality rate, age-standardized incidence rate, age-standardized mortality rate, and the average annual percent change (AAPC) were calculated, and trend analyses were performed.[Results] In 2021, the crude incidence rate of leukemia in Zhejiang Province was 10.19 per 100,000, and the age-standardized incidence rate was 6.50 per 100,000. The crude mortality rate was 5.06 per 100,000, and the age-standardized mortality rate was 2.53 per 100,000. Both incidence and mortality levels were higher in males than in females. The peak incidence age group was 80-84 years, while the peak mortality age group was ≥85 years. From 2000 to 2021, both the crude incidence rate (AAPC=3.27%, P<0.001) and the age-standardized incidence rate (AAPC=1.34%, P<0.001) showed increasing trends in Zhejiang Province. The increases in both crude and age-standardized incidence rates were greater in males than in females, and greater in rural areas than in urban areas. During the same period, the crude mortality rate (AAPC=4.79%, P<0.001) and age-standardized mortality rate (AAPC=2.26%, P<0.05) also exhibited upward trends. The crude mortality rates of men and women and the age-standardized mortality rate of men showed an upward trend consistent with the overall situation. In urban areas, both crude and age-standardized mortality rates increased, whereas in rural areas, the crude mortality rate increased but the age-standardized mortality rate decreased.[Conclusion] In 2021, the incidence and mortality levels of leukemia in Zhejiang Province were higher than the national average, with a continuous upward trend from 2000 to 2021. Infants, young children, and the elderly population should be considered priority groups. Enhanced health education and exposure risk prevention and control measures targeting high-risk populations are recommended, along with improved early diagnosis and treatment rates. |
