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2021年浙江省肿瘤登记地区卵巢癌发病与死亡特征及2000—2021年变化趋势分析

Incidence and Mortality of Ovarian Cancer in Zhejiang Cancer Registration Areas in 2021 and Trends from 2000 to 2021

投稿时间：2026-07-16 修订日期：2026-08-11

DOI：

中文关键词: 卵巢癌发病率死亡率趋势分析浙江

英文关键词:ovarian cancer incidence mortality trend analysis Zhejiang

基金项目:

作者	单位	邮编
孙强	宁波市鄞州区疾病预防控制中心	315100
李小勇	宁波市鄞州区疾病预防控制中心	315100
沈鹏	宁波市鄞州区疾病预防控制中心	315100
林高峰	宁波市鄞州区疾病预防控制中心	315100
赵磊	宁波市鄞州区疾病预防控制中心	315100
杜灵彬	浙江省肿瘤医院	310022
李辉章^*	浙江省肿瘤医院	310022

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中文摘要:

摘要：[目的] 分析2021年浙江省肿瘤登记地区卵巢癌发病与死亡特征及2000—2021年变化趋势。 [方法] 基于浙江省22个肿瘤登记处报告的2000—2021年卵巢癌监测数据，描述卵巢癌发病与死亡的粗率、中国标准人口年龄标化率（age-standardized rate by Chinese standard population , ASRC）、世界标准人口年龄标化率（age-standardized rate by world standard population , ASRW）、累积率(0~74岁)和截缩率(35~64岁)等指标，其长期变化趋势通过Joinpoint回归模型进行拟合，估计平均年度变化百分比(average annual percentage change , AAPC)、年度变化百分比(annual percentage change , APC)及其95%置信区间(confidence interval , CI)。[结果] 2021年浙江省肿瘤登记地区报告卵巢癌新发病例数1 004例，中标发病率为5.77/10万。同期报告卵巢癌死亡病例434例，中标死亡率为1.95/10万。农村地区中标发病率（6.36/10万）高于城市地区（5.42/10万），但中标死亡率（1.83/10万）低于城市地区（2.03/10万）。发病与死亡高峰分别出现在65~69岁组（19.43/10万）和80~84岁组（17.79/10万）。2000—2021年卵巢癌中标发病率总体变化趋势无统计学意义(P0.05)，而城乡趋势显著相反。城市地区中标发病率呈下降趋势 (AAPC=-1.55% , 95%CI：-2.12%~-0.95% , P0.001)，农村地区则明显上升 (AAPC=3.70% , 95%CI：2.49%~5.00% , P0.001)。同期，卵巢癌中标死亡率总体呈上升趋势 (AAPC=1.92% , 95%CI：0.65%~3.29% , P=0.006)，其中城市地区上升趋势明显 (AAPC=2.15% , 95%CI：0.97%~3.41% , P=0.001)，农村地区变化无统计学意义(P0.05)。[结论] 浙江省卵巢癌的总体疾病负担低于全国平均水平，但存在显著的城乡差异。未来需在农村地区重点控制危险因素以遏制发病增长，同时在城市地区着力强化早筛早治以降低死亡风险。

英文摘要:

Abstract：[Purpose ]To investigate the incidence and mortality characteristics of ovarian cancer in Zhejiang cancer registration areas in 2021 and trends from 2000 to 2021. [Methods] Based on ovarian cancer surveillance data reported by 22 cancer registries in Zhejiang Province from 2000 to 2021, the crude rates, age-standardized rates by the Chinese standard population (ASRC) and by the world standard population (ASRW), cumulative rates (0~74 years), and truncated rates (35~64 years) for both incidence and mortality were described. Long-term trend of ovarian cancer incidence and mortality was fitted with the Joinpoint regression model, yielding estimates of the average annual percentage change (AAPC), annual percentage change (APC), and their 95% confidence intervals (CI). [Results] In 2021, A total of 1 004 new ovarian cancer cases were reported in Zhejiang cancer registration areas, with the ASIRC of 5.77/105. There were 434 ovarian cancer deaths, with the ASMRC of 1.95/105. The ASIRC in rural areas was 6.36/105, which was higher than that in urban areas (5.42/105), while the ASMRC in rural areas was 1.83/10?, which was lower than that in urban areas (2.03/105). The incidence peak occurred in the 65-69 years age group (19.43/105), and the mortality peak in the 80-84 ?years age group (17.79/105). From 2000 to 2021, the overall ASIRC showed no significant change (P0.05), but trends differed between urban and rural areas: a decline in urban areas (AAPC=-1.55% , 95%CI：-2.12%~-0.95% , P0.001) and a significant increase in rural areas (AAPC=3.70% , 95%CI：2.49%~5.00% , P0.001). The overall ASMRC rose significantly (AAPC=1.92% , 95%CI：0.65%~3.29% , P=0.006), driven mainly by an increase in urban areas (AAPC=2.15% , 95%CI：0.97%~3.41% , P=0.001), while no significant change was observed in rural areas (P0.05). [Conclusion] The overall disease burden of ovarian cancer in Zhejiang Province is lower than the national average, but there are marked urban-rural differences. In the future, it is necessary to focus on controlling risk factors in rural areas to curb the increase in incidence, while strengthening early screening and treatment in urban areas to reduce mortality risk.

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