| 赵 群,李 勇,乔 喜.胃癌组织中Her-2蛋白的过表达与临床病理的相关分析[J].肿瘤学杂志,2015,21(5):360-364. |
| 胃癌组织中Her-2蛋白的过表达与临床病理的相关分析 |
| Correlation Between Overexpression of Her-2 Protein and Clinicopathology in Gastric Cancer |
| 投稿时间：2015-03-04 |
| DOI：10.11735/j.issn.1671-170X.2015.05.B002 |
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| 中文关键词: 胃肿瘤 Her-2 免疫组织化学 临床病理学 |
| 英文关键词:gastric neoplasms Her-2 immunohistochemistry clinicopathology |
| 基金项目:河北省自然科学基金(H2013206311) |
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| 中文摘要: |
| 摘 要：［目的］ 研究胃癌患者术前胃镜咬检、术后标本组织中人表皮生长因子受体2（Her-2）表达的一致性，探讨术后标本组织中Her-2蛋白的过表达及其与临床病理的关系。［方法］ 选取前瞻性、多中心、开放、随机对照Ⅲ期临床试验(NCT01516944)中277例直接手术的进展期胃癌患者，采用免疫组织化学法（IHC）检测其术前胃镜活检、术后标本组织Her-2蛋白的表达情况，其中2+和3+认为是Her-2蛋白过表达（简称Her-2的过表达），并分析Her-2过表达与患者性别、年龄、肿瘤部位、Lauren分型、分化程度、浸润深度、淋巴结转移、远处转移、TNM分期、脉管瘤栓、神经受侵的相关性。［结果］ 277例胃癌患者中术前胃镜咬检组织的Her-2的过表达率为32.85%，其中3+的有23例；术后标本组织的Her-2的过表达率为29.60%，其中3+的有21例，两者差异无统计学意义（P=0.711）。所有术后患者的Her-2过表达与肿瘤分化、浸润深度、淋巴转移、TNM分期等存在明显关系（P＜0.05），与患者年龄、性别、肿瘤部位、Lauren分型、远处转移等无明显关系（P＞0.05）。［结论］ 术前胃镜咬检、术后标本组织中Her-2表达基本一致；随着胃癌浸润深度、淋巴转移、TNM分期增加，Her-2蛋白过表达率随之增加，并且Her-2蛋白过表达率在中分化胃癌中所占比例较大。 |
| 英文摘要: |
| Abstract：［Purpose］To analyze the consistency of human epidermal growth factor receptor-2 (Her-2) expression in preoperative gastroscopic biopsy tissues and in postoperative specimens in patients with gastric cancer，and to investigate the relation of Her-2 overexpression in postoperative specimens with clinicopathology of gastric cancer .［Methods］Two hundred and seventy-seven cases of advanced gastric cancer with surgery alone from prospective，multicenter，open，randomized，controlled Ⅲ phase clinical trial(NCT01516944) were enrolled in the study. Her-2 overexpression in preoperative gastroscopic biopsy tissues and in postoperative specimens was detected by immunohistochemical method(IHC)，and Her-2 expression with 2+ or 3+ was considered as overexpression. The relation of Her-2 overexpression with gender，age，tumor location，Lauren classification，differentiation grade，depth of invasion，lymph node metastasis，distant metastasis，TNM stage，vascular invasion，neural invasion was analyzed.［Results］Her-2 overexpression in preoperative gastroscopic biopsy tissues of 277 cases with gastric cancer was 32.85%，with 3+ of 23 cases；and that in postoperative specimens was 29.60%，with 3+ of 21 cases. There was no significant difference between them(P=0.711). Her-2 overexpression in postoperative specimens had significant correlation with the grade of differentiation，depth of invasion，lymph node metastasis，TNM staging(P<0.05)，and had no correlation with patient’s age，gender，tumor location，Lauren classification，distant metastasis (P>0.05).［Conclusions］ Her-2 expression in preoperative gastroscopic biopsy tissues is consistent with that in postoperative specimens. Her-2 overexpression rate increases with the increasing of depth of invasion，lymph node metastasis，and TNM stage，and the overexpression occupies a large proportion in gastric cancer with moderate differentiation. |
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