| 刘 瑾,高 源,徐 农.胃癌靶向治疗的现状和研究进展[J].肿瘤学杂志,2018,24(12):1147-1152. |
| 胃癌靶向治疗的现状和研究进展 |
| Targeted Therapy in Gastric Cancer：Current Status and Prospect |
| 投稿时间：2018-08-26 |
| DOI：10.11735/j.issn.1671-170X.2018.12.B002 |
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| 中文关键词: 胃肿瘤 靶向治疗 |
| 英文关键词:gastric cancer targeted therapy |
| 基金项目:浙江省重大科技专项重大社会发展项目（2014C03040-2）；国家卫生和计划生育委员会科研基金-浙江省医药卫生重大科技计划项目（KWJ-ZJ-1802） |
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| 中文摘要: |
| 摘 要：胃癌是东亚高发恶性肿瘤之一。在中国，60%的胃癌患者初诊时即为进展期，多数患者需要内科药物治疗。靶向治疗是针对肿瘤特有靶点的药物治疗，但是由于胃癌异质性强等原因，有关胃癌靶向治疗的临床研究成功的少、失败的多。“以一概全”的传统治疗方法显然不能满足个体化精准治疗的要求，基于合适的分子标志选择患者人群可能是研究成功的关键。全文就胃癌分子靶向药物治疗的现状、正在进行的临床研究和未来的方向作一综述。 |
| 英文摘要: |
| Abstract：Gastric cancer is one of the most common malignant tumors all over the world，especially in East Asia. About 60% of newly diagnosed patients in China were in advanced stages with highly heterogeneous characteristics；and most patients required systematic medical treatment. Targeted therapy is the anti-tumor treatment focusing on specific targets；however，most clinical trials of targeted agents in gastric cancer had failed. With the development of anti-tumor therapy，the traditional therapeutic pattern of “one-size-fits-all” could not meet the requirements of individualized precision treatment. The success of clinical researches might rely on the selection of patients based on appropriate molecular biomarkers. The current status of targeted therapy in gastric cancer，as well as ongoing clinical researches and future research directions are reviewed in this article. |
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