| 王 慧,刘晓娟,毋 艳.三种挽救化疗方案对初始诱导失败/复发AML患者的疗效及安全性分析[J].肿瘤学杂志,2018,24(12):1196-1200. |
| 三种挽救化疗方案对初始诱导失败/复发AML患者的疗效及安全性分析 |
| Efficacy and Safety of Three Salvage Chemotherapy Regimens for Patients with Refractory/Relapsed Acute Myeloid Leukemia |
| 投稿时间：2017-09-04 |
| DOI：10.11735/j.issn.1671-170X.2018.12.B011 |
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| 中文关键词: FLAG CAG MAC 挽救化疗 急性髓系白血病 |
| 英文关键词:FLAG CAG MAC salvage chemotherapy acute myeloid leukemia |
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| 中文摘要: |
| 摘 要：［目的］探讨FLAG、CAG及MAC方案对初始诱导失败/复发AML患者疾病缓解率、生存时间及毒副作用的影响。［方法］ 150例诱导失败/复发AML患者，根据治疗方案不同分为FLAG组（50例）、CAG组（50例）及MAC组（50例），比较三组患者疾病缓解率、中位无进展生存时间、中位总生存时间及毒副作用发生率。［结果］ MAC组患者完全缓解率高于FLAG、CAG组（P<0.05）；三组患者部分缓解率比较差异无统计学意义（P>0.05）；MAC组患者总体反应率显著高于FLAG组（P<0.05）。三组患者中位无进展生存时间比较差异无统计学意义（P>0.05）；MAC组患者中位总生存时间长于FLAG、CAG组（P<0.05）。三组患者肝功能损伤、肾功能损伤、腹泻及恶心呕吐发生率比较差异均无统计学意义（P>0.05）；CAG、MAC组患者Ⅰ～Ⅱ度继发感染发生率均显著高于FLAG组（P<0.05）；但三组患者Ⅲ～Ⅳ度继发感染发生率比较差异无统计学意义（P>0.05）。［结论］ 相较于FLAG和CAG方案，MAC方案治疗初始诱导失败/复发AML可有效提高疾病缓解率，延长总生存时间，且未增加严重毒副作用发生风险。 |
| 英文摘要: |
| Abstract：［Objective］ To assess the efficacy and safety of FLAG，CAG and MAC regimens in treatment of patients with refractory/relapsed acute myeloid leukemia(AML). ［Methods］ One hundred and fifty patients with refractory/relapsed AML were enrolled and randomly assigned to receive FLAG，CAG or MAC regimens for salvage chemotherapy with 50 cases in each group. And the disease remission，the median progression?鄄free survival(PFS)，the median overall survival(OS) and the incidence of adverse effects in three groups were compared. ［Results］ The complete remission rate of MAC group were significant higher than that in FLAG group and CAG group(P<0.05). There was no significant difference in the partial remission rate among three groups(P>0.05). The overall response rate in MAC group was significant higher than that in FLAG group(P<0.05). There was no significant difference in the median PFS among three groups(P>0.05). The median OS in MAC group were significant longer than that in FLAG group and CAG group(P<0.05). There was no significant difference in the incidence of liver dysfunction，renal dysfunction，diarrhea and vomit among three groups(P>0.05). The incidence of Ⅰ～Ⅱ degree infection in CAG group and MAC group was significant higher than that in FLAG group(P<0.05). There was no significant difference in the incidence of Ⅲ～Ⅳ degree infection among three groups(P>0.05). ［Conclusion］ Compared with FLAG and CAG regimen，MAC regimen can efficiently improve the disease remission prolong the survival time without increasing risk of serious adverse reactions in treatment of patients with refractory/relapsed AML. |
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