李 岚,宋启斌,刘立柏.PD-L1表达调控研究进展[J].肿瘤学杂志,2019,25(3):185-191.
PD-L1表达调控研究进展
Research Progresses on Expression Mechanisms of PD-L1
投稿时间:2018-04-15  
DOI:10.11735/j.issn.1671-170X.2019.03.B002
中文关键词:  肿瘤  免疫逃逸  PD-L1  表达调控
英文关键词:tumor  immune escape  PD-L1  expressing regulation
基金项目:
作者单位
李 岚 武汉大学第一临床学院 
宋启斌 武汉大学人民医院 
刘立柏 武汉大学第一临床学院 
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中文摘要:
      摘 要:PD-1/PD-L1信号通路是肿瘤免疫逃逸主要机制之一。通过单克隆抗体与配体或受体结合阻断PD-1和PD-L1之间的相互作用在如黑色素瘤、非小细胞肺癌等多种肿瘤患者中疗效显著,但是只对部分患者有效。已开展的临床研究发现患者肿瘤部位的PD-L1表达量可能与PD-1/PD-L1抑制剂的疗效及预后相关。因此,深入研究PD-L1的表达调控机制有利于为肿瘤免疫治疗提供新的思路和潜在靶点,改进PD-1/PD-L1抑制剂的疗效。全文将PD-L1表达调控分为转录水平和转录后水平,对近几年PD-L1表达调控研究进展作一综述。
英文摘要:
      Abstract:PD-1/PD-L1 signaling pathway is one of the main mechanisms of tumor immune escape. Monoclonal antibodies which block the interaction between PD-1 and PD-L1 have shown promising outcomes in various cancers,such as melanoma,non-small-cell lung cancer. But only a proportion of patients responds to the therapy. PD-L1 expression seems to correlate with the efficacy of PD-1/PD-L1 inhibitors and the clinical outcomes. Understanding the regulation mechanisms of PD-L1 would provide the new targets for tumor immunotherapy and improve the efficacy of PD-1/PD-L1 inhibitors.
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