| 姚云峰,王宝成,王 俊.促凋亡蛋白Bim在肿瘤治疗中的研究进展[J].肿瘤学杂志,2019,25(3):247-251. |
| 促凋亡蛋白Bim在肿瘤治疗中的研究进展 |
| Research Progress on Pro-apoptotic Protein Bim in Tumor Therapy |
| 投稿时间：2017-12-10 |
| DOI：10.11735/j.issn.1671-170X.2019.03.B015 |
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| 中文关键词: 肿瘤 Bim 凋亡 靶向治疗 |
| 英文关键词:tumor Bim apoptosis targeted therapy |
| 基金项目:国家自然科学基金（81572875及81272619） |
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| 中文摘要: |
| 摘 要：Bim(Bcl-2 interacting mediator of cell death)是Bcl-2家族中BH3-only亚家族的成员，是一种重要的凋亡调节蛋白，在维持内环境稳定中有着重要的作用。Bim蛋白低表达与人类多种肿瘤的发生、发展和预后相关，为基因治疗提供新靶点。另外，Bim在肿瘤的化疗及靶向治疗中也起到十分重要的作用。 |
| 英文摘要: |
| Abstract：The pro-apoptotic protein Bim (Bcl-2 interacting mediator of cell death) is a member of BH3-only subfamily in BCL-2 family. Bim works in concert with other pro-apoptotic proteins and anti-apoptotic proteins to regulate cell death and survival which is essential for normal tissue homeostasis. Reduced Bim expression is associated with the occurrence，development and prognosis of many human tumors，suggesting that it provides a new target for gene therapy. In addition，Bim plays an important role in tumor chemotherapy and targeted therapy. In this article we review the recent progress on Bim protein in cancer therapy and its perspective. |
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