陈雨甜,徐 红,陈红玲,等.白介素-17及其相关信号通路支持幽门螺杆菌诱导胃癌发生的机制研究进展[J].肿瘤学杂志,2023,29(10):840-846.
白介素-17及其相关信号通路支持幽门螺杆菌诱导胃癌发生的机制研究进展
Research Progress of IL-17 and Its Signaling Pathways Mediate Helicobacter Pylori Inducing Gastric Cancer
投稿时间:2023-06-06  
DOI:10.11735/j.issn.1671-170X.2023.10.B006
中文关键词:  胃肿瘤  白介素-17  幽门螺杆菌  肿瘤免疫微环境  髓源性抑制细胞  T细胞耗竭
英文关键词:gastric cancer  interleukin-17  Helicobacter pylori  tumor immune microenvironment  myeloid-derived suppressor cells  T cell exhaustion
基金项目:
作者单位
陈雨甜 苏州大学附属第一医院 
徐 红 苏州大学附属第一医院 
陈红玲 苏州大学附属第一医院 
陈 洁 苏州大学附属第一医院 
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中文摘要:
      摘 要:幽门螺杆菌感染作为胃癌的Ⅰ类致癌原,其引起的慢性炎症-萎缩性胃炎-萎缩性胃炎伴肠上皮化生-异型增生而逐渐向胃癌演变,而IL-17作为关键的促炎细胞因子之一,IL17+细胞和相关信号通路参与胃癌的发生、进展,并与胃癌预后不良相关。全文综述IL-17介导胃癌发生、进展、治疗耐药、转移的可能机制,包括促进细胞增殖、抑制细胞凋亡,创造免疫耐受微环境,诱导T细胞耗竭,持续的血管生成,以及诱导上皮-间充质转化。
英文摘要:
      Abstract: Helicobacter pylori infection, as a classⅠcarcinogen of gastric cancer, causes chronic inflammation evolving to atrophic gastritis, intestinal metaplasia, dysplasia, and eventually to gastric cancer. IL-17, as one of the key pro-inflammatory cytokines, is involved in the occurrence and progression of gastric cancer; and IL-17+ cells and related signaling pathways are closely associated with poor prognosis of gastric cancer. This paper reviews the possible mechanisms by which IL-17 mediates the progression, metastasis and treatment resistance of gastric cancer, including promoting cell proliferation, inhibiting cell apoptosis, creating an immune-tolerant microenvironment, causing T cell exhaustion, sustaining angiogenesis, and inducing epithelial-mesenchymal transition.
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