王存福,郭 驹.非编码RNA调节肝癌干细胞的研究进展[J].肿瘤学杂志,2023,29(10):878-884.
非编码RNA调节肝癌干细胞的研究进展
Research Progress on Non-Coding RNA’s Regulation of Liver Cancer Stem Cells
投稿时间:2023-06-24  
DOI:10.11735/j.issn.1671-170X.2023.10.B011
中文关键词:  肝癌干细胞  生物标志物  非编码RNA  自我更新  分化
英文关键词:liver cancer stem cell  biomarker  non-coding RNA  self-renewal  differentiation
基金项目:
作者单位
王存福 广西中医药大学附属瑞康医院 
郭 驹 南方医科大学第五附属医院 
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中文摘要:
      摘 要: 肝癌是一种侵袭性极强的恶性肿瘤,临床预后极差。肝癌干细胞(liver cancer stem cells,LCSCs)是肝癌细胞中一类具有自我更新和多向分化潜能的细胞亚群,具有极强的侵袭、迁移能力,与肝癌的发生、进展、转移密切相关。非编码RNA(non-coding RNAs,ncRNAs) 是癌症干细胞(cancer stem cells,CSCs)亚群的关键调节因子,参与了CSCs的自我更新、侵袭、耐药和分化等过程。全文对ncRNAs在LCSCs发生、维持和调节中的功能及作用机制等近年来研究进展作一综述:通过ncRNAs寻找肝癌治疗新靶点,以期选择性消除LCSCs,最终改善肝癌患者的预后。
英文摘要:
      Abstract: Liver cancer is a highly aggressive malignant tumor with a very poor clinical prognosis. Liver cancer stem cells (LCSCs) are a subpopulation of cells with self-renewal and multi-directional differentiation potential in liver cancer cells, which have strong invasion and migration capabilities, and are closely related to the occurrence, progression and metastasis of liver cancer. Non-coding RNAs (ncRNAs) are a key regulator of cancer stem cells(CSCs) subsets, which are involved in CSCs self-renewal, invasion, drug resistance and differentiation. This paper reviews the research progress on function and mechanism of ncRNAs in the initiation, maintenance and regulation of LCSCs in recent years, and uses ncRNAs to find new targets for the treatment of liver cancer, in order to selectively eliminate LCSCs and ultimately improve the prognosis of liver cancer patients.
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