| 姜 华,张 贺,江松松.PKM2及PD-L1在前列腺癌组织中的表达及其临床意义[J].肿瘤学杂志,2025,31(2):157-162. |
| PKM2及PD-L1在前列腺癌组织中的表达及其临床意义 |
| Expression of PKM2 and PD-L1 in Prostate Cancer and Its Clinicopathological Significance |
| 投稿时间：2024-04-21 |
| DOI：10.11735/j.issn.1671-170X.2025.02.B011 |
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| 中文关键词: 前列腺肿瘤 丙酮酸激酶 M2 PD-L1 免疫逃逸 |
| 英文关键词:prostate neoplasms pyruvate kinase M2 PD-L1 immune evasion |
| 基金项目:广东省基础与应用基础研究基金项目（2022A1515220218）；贵州省科技计划项目（黔科合基础-ZK［2022］一般633）；贵州省科技支撑计划（一般项目）项目（黔科合支撑［2023］一般262）；广东省医学科研基金项目（B2023140）；遵义医科大学博士科研启动基金项目（BS2022-01） |
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| 中文摘要: |
| 摘 要：［目的］ 探讨丙酮酸激酶 M2（pyruvate kinase M2，PKM2）和 PD-L1在前列腺癌组织中的表达及其相关性。［方法］ 采用免疫组化（immunohistochemistry，IHC）技术，对58例前列腺癌患者肿瘤组织及58例良性前列腺增生组织切片进行PKM2和PD-L1的表达检测。根据染色强度和阳性细胞百分比，量化两种蛋白的表达水平。分析PKM2和PD-L1表达与临床病理特征（包括TNM分期、年龄、前列腺特异性抗原、淋巴结转移和Gleason评分）之间的关系。采用SPSS 26.0统计软件进行数据分析。［结果］ PKM2和PD-L1在前列腺癌组织中的阳性表达率显著高于良性前列腺增生组织（PKM2：89.7% vs 15.5%，P＜0.001；PD-L1：79.3% vs 41.4%，P＜0.001）。前列腺癌组织中PKM2的表达与Gleason评分和TNM分期有关（P＜0.001，P=0.034），PD-L1的表达也与Gleason评分和TNM分期有关（P＜0.001，P=0.035）；两者的表达均与患者年龄、前列腺特异性抗原水平和淋巴结转移无关（P均>0.05）。前列腺癌组织中PD-L1与PKM2表达呈正相关（r=0.814 1，P＜0.001）。 ［结论］ PKM2和 PD-L1在前列腺癌中的高表达与肿瘤进展相关。 PKM2 可能通过增加PD-L1的表达而参与免疫调控。 |
| 英文摘要: |
| Abstract： ［Objective］ To investigate the expression of pyruvate kinase M2 (PKM2) and programmed death-ligand 1 (PD-L1) in prostate cancer (PCa) and benign prostatic hyperplasia (BPH) tissues， and to explore their clinicopathological significance. ［Methods］ The expression of PKM2 and PD-L1 in tissue samples from 58 PCa patients and 58 BPH patients were detected by immunohistochemistry (IHC) . The relationship between the expression of PKM2 and PD-L1 and clinicapathological features， including TNM stage， prostate-specific antigen (PSA)， lymph node metastasis and Gleason score were analyzed. Statistical analysis was carried out by SPSS 26.0 statistical software. ［Results］ The positive expression rates of PKM2 and PD-L1 in PCa tissue were significantly higher than those in BPH tissue (PKM2： 89.7% vs 15.5%， P＜0.001； PD-L1：79.3% vs 41.4%， P＜0.001). The expression of PKM2 in PCa was correlated to Gleason score and TNM stage (P<0.001， P=0.034)， and the expression of PD-L1 was also correlated to Gleason score and TNM stage (P<0.001， P=0.035). While the the expression of PKM2 and PD-L1 was not correlated with the patient age， PSA level and lymph node metastasis (all P>0.05). PD-L1 was positively correlated with PKM2 expression in PCa tissue (r=0.814 1， P＜0.001). ［Conclusion］ The expression of PKM2 and PD-L1 is associated with the progression of PCa. PKM2 may be involved in immune regulation by enhancing the expression of PD-L1. |
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