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| 胃肠胰高级别神经内分泌肿瘤病理诊断现状及进展 |
| High grade gastroenteropancreatic neuroendocrine neoplasm current status and progress of pathological diagnosis |
| 投稿时间：2024-01-28 修订日期：2024-03-29 |
| DOI： |
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| 中文关键词: 胃肠胰 神经内分泌瘤G3 神经内分泌癌 |
| 英文关键词:Gastroenteropancreatic Neuroendocrine Tumor G3 Neuroendocrine carcinoma |
| 基金项目:浙江省医药卫生科技临床研究应用项目 |
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| 中文摘要: |
| 胃肠胰神经内分泌肿瘤根据目前WHO消化系统肿瘤分类中的分级标准可分为低、高级别肿瘤，其中高级别肿瘤包括了分化良好的神经内分泌瘤G3和低分化神经内分泌癌，两者临床病理特征和治疗决策显著不同，是病理诊断工作中的难点，如何较为精准的区分它们至关重要。本文归纳总结了目前研究中所涉及的这两类肿瘤病理诊断标准以及相关免疫组化、分子标记物研究进展，旨在为临床正确认识该类疾病并制定适宜的精准治疗方案提供更可靠的依据。 |
| 英文摘要: |
| Gastroenteropancreatic neuroendocrine neoplasm can be classified into low-grade and high-grade tumors according to the current WHO classification criteria for digestive system tumors. Among them, high-grade tumors include well differentiated neuroendocrine tumors G3 and poorly differentiated neuroendocrine cancers. The clinical pathological characteristics and treatment decisions of the two are significantly different, which is a difficult point in pathological diagnosis. It is crucial to accurately distinguish them. This article summarizes the pathological diagnostic criteria and related immunohistochemical and molecular marker research progress of these two types of tumors currently involved in research, Intended to provide a more reliable basis for clinical correct understanding of this type of disease and the development of appropriate precision treatment plans. |
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