何 瀚,黄 荣,蒋 军.放疗对非小细胞肺癌患者循环肿瘤细胞数目的影响[J].肿瘤学杂志,2019,25(5):402-404.
放疗对非小细胞肺癌患者循环肿瘤细胞数目的影响
Effect of Radiotherapy on Circulating Tumor Cells in Patients with Non-Small Cell Lung Cancer
投稿时间:2019-01-07  
DOI:10.11735/j.issn.1671-170X.2019.05.B004
中文关键词:  循环肿瘤细胞  非小细胞肺癌  放疗
英文关键词:circulating tumor cells  non-small cell lung cancer  radiotherapy
基金项目:
作者单位
何 瀚 佛山市第一人民医院 
黄 荣 佛山市第一人民医院 
蒋 军 佛山市第一人民医院 
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中文摘要:
      摘 要:[目的] 探讨放疗对非小细胞肺癌(non-small cell lung cancer,NSCLC)患者循环肿瘤细胞(CTCs)的影响。[方法] 选取42例NSCLC患者为研究对象,比较放疗前后CTCs数目的变化情况,并分析各亚组治疗前后CTCs数目的改变。[结果] 放疗前CTCs数目与患者性别、年龄、吸烟状况及临床分期的无关。与放疗前比较,放疗后CTCs数目下降明显(P<0.001);男性、年龄>60岁及吸烟患者治疗后CTCs数目下降有统计学意义。[结论] 放疗可以在不同程度上降低CTCs数目,但不同患者异质性较大,需个体化分析和判断。
英文摘要:
      Abstract:[Objective] To investigate the effect of radiotherapy on circulating tumor cells (CTCs) in patients with non-small cell lung cancer (NSCLC). [Methods] Forty-two patients with NSCLC were enrolled in the study. The changes in the number of CTCs before and after radiotherapy were compared. [Results] The number of CTCs before radiotherapy was not related to gender,age,smoking status and clinical stage of patients. Compared with that before radiotherapy,the number of CTCs decreased significantly after radiotherapy(P<0.001). The stratified analysis showed that the number of CTCs after radiotherapy was significantly associated with concurrent chemotherapy,male sex,smoking,and age >60 years(P<0.05). [Conclusion] Radiotherapy can reduce the number of CTCs,which is related to age,gender,smoking status and concurrent chemotherapy of patients.
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